PMID- 12139225
OWN - NLM
STAT- MEDLINE
DCOM- 20020820
LR  - 20190605
IS  - 0002-9637 (Print)
IS  - 0002-9637 (Linking)
VI  - 66
IP  - 3
DP  - 2002 Mar
TI  - Helminth infections are associated with protection from cerebral malaria and 
      increased nitrogen derivatives concentrations in Thailand.
PG  - 304-9
AB  - Following a study showing an association between Ascaris and protection from 
      cerebral malaria, we hypothesized helminths may have induced protection through 
      immunoglobulin E (IgE) and the CD23/NO pathway. We compared the prevalence of 
      helminth infections in 67 cerebral malaria patients and 217 hyperparasitemic 
      controls with no complications. For 24 cerebral malaria cases and 56 controls, we 
      compared reactive nitrogen intermediates (RNI) concentrations and their 
      correlations to total IgE and sCD23 concentrations in helminth-infected and 
      noninfected patients. We observed a dose-dependent association between helminth 
      infections and protection from cerebral malaria (adjusted odds ratio [OR] = 0.36, 
      95% CI = 0.19-0.7, P = 0.002, linear trend P = 0.0007). Helminth-infected 
      controls had higher RNI concentrations than those without helminths: 72 OD +/- 19 
      SD and 57 OD +/- 20 SD, respectively (P = 0.006). Logistic regression, including 
      interaction terms between RNI and sCD23, showed that an increase of RNI could be 
      both protective and pathogenic depending on the concentration of sCD23. Helminths 
      increasing both the CD23 receptor and its ligand may have a role in the 
      establishment of malaria tolerance through the CD23/NO pathway.
FAU - Nacher, Mathieu
AU  - Nacher M
AD  - Unite INSERM 511: Immunobiologie Cellulaire et Moleculaire des Infections 
      Parasitaires, Faculte de Medecine Pitie-Salpetriere, Paris, France. 
      m_nacher@mailcity.com
FAU - Singhasivanon, Pratap
AU  - Singhasivanon P
FAU - Traore, Boubacar
AU  - Traore B
FAU - Vannaphan, Suparp
AU  - Vannaphan S
FAU - Gay, Frederick
AU  - Gay F
FAU - Chindanond, Duangrudee
AU  - Chindanond D
FAU - Franetich, Jean Francois
AU  - Franetich JF
FAU - Mazier, Dominique
AU  - Mazier D
FAU - Looareesuwan, Sornchai
AU  - Looareesuwan S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Trop Med Hyg
JT  - The American journal of tropical medicine and hygiene
JID - 0370507
RN  - 0 (Receptors, IgE)
RN  - 31C4KY9ESH (Nitric Oxide)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - Case-Control Studies
MH  - Helminthiasis/*complications/parasitology
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Logistic Models
MH  - Malaria, Cerebral/*complications/*immunology/parasitology
MH  - Nitric Oxide/*metabolism
MH  - Odds Ratio
MH  - Parasitemia/parasitology
MH  - *Plasmodium falciparum
MH  - Receptors, IgE/metabolism
MH  - Thailand
EDAT- 2002/07/26 10:00
MHDA- 2002/08/21 10:01
CRDT- 2002/07/26 10:00
PHST- 2002/07/26 10:00 [pubmed]
PHST- 2002/08/21 10:01 [medline]
PHST- 2002/07/26 10:00 [entrez]
AID - 10.4269/ajtmh.2002.66.304 [doi]
PST - ppublish
SO  - Am J Trop Med Hyg. 2002 Mar;66(3):304-9. doi: 10.4269/ajtmh.2002.66.304.