PMID- 12140784
OWN - NLM
STAT- MEDLINE
DCOM- 20030211
LR  - 20220330
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 7
IP  - 6
DP  - 2002
TI  - Early maternal deprivation reduces the expression of BDNF and NMDA receptor 
      subunits in rat hippocampus.
PG  - 609-16
AB  - It is well accepted that events that interfere with the normal program of 
      neuronal differentiation and brain maturation may be relevant for the etiology of 
      psychiatric disorders, setting the stage for synaptic disorganization that 
      becomes functional later in life. In order to investigate molecular determinants 
      for these events, we examined the modulation of the neurotrophin brain-derived 
      neurotrophic factor (BDNF) and the glutamate NMDA receptor following 24 h 
      maternal separation (MD) on postnatal day 9. We found that in adulthood the 
      expression of BDNF as well as of NR-2A and NR-2B, two NMDA receptor forming 
      subunits, were significantly reduced in the hippocampus of MD rats whereas, among 
      other structures, a slight reduction of NR-2A and 2B was detected only in 
      prefrontal cortex. These changes were not observed acutely, nor in pre-weaning 
      animals. Furthermore we found that in MD rats the modulation of hippocampal BDNF 
      in response to an acute stress was altered, indicating a persistent functional 
      impairment in its regulation, which may subserve a specific role for coping with 
      challenging situations. We propose that adverse events taking place during brain 
      maturation can modulate the expression of molecular players of cellular 
      plasticity within selected brain regions, thus contributing to permanent 
      alterations in brain function, which might ultimately lead to an increased 
      vulnerability for psychiatric diseases.
FAU - Roceri, M
AU  - Roceri M
AD  - Center of Neuropharmacology, Department of Pharmacological Sciences and Center of 
      Excellence for Neurodegenerative Disorders, University of Milan, Milan, Italy.
FAU - Hendriks, W
AU  - Hendriks W
FAU - Racagni, G
AU  - Racagni G
FAU - Ellenbroek, B A
AU  - Ellenbroek BA
FAU - Riva, M A
AU  - Riva MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (NR2A NMDA receptor)
RN  - 0 (NR2B NMDA receptor)
RN  - 0 (Protein Subunits)
RN  - 0 (RNA Probes)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Female
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/*physiology
MH  - Male
MH  - *Maternal Deprivation
MH  - Protein Subunits/genetics
MH  - RNA Probes
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, N-Methyl-D-Aspartate/*genetics
MH  - Reference Values
EDAT- 2002/07/26 10:00
MHDA- 2003/02/13 04:00
CRDT- 2002/07/26 10:00
PHST- 2001/07/25 00:00 [received]
PHST- 2001/10/16 00:00 [revised]
PHST- 2001/11/14 00:00 [accepted]
PHST- 2002/07/26 10:00 [pubmed]
PHST- 2003/02/13 04:00 [medline]
PHST- 2002/07/26 10:00 [entrez]
AID - 10.1038/sj.mp.4001036 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2002;7(6):609-16. doi: 10.1038/sj.mp.4001036.