PMID- 12142470
OWN - NLM
STAT- MEDLINE
DCOM- 20030909
LR  - 20220330
IS  - 0362-1642 (Print)
IS  - 0362-1642 (Linking)
VI  - 43
DP  - 2003
TI  - Retinoid receptors and their coregulators.
PG  - 47-72
AB  - Retinoids regulate gene transcription by binding to the nuclear receptors, the 
      retinoic acid (RA) receptors (RARs), and the retinoid X receptors (RXRs). RARs 
      and RXRs are ligand-activated transcription factors for the regulation of 
      RA-responsive genes. The actions of RARs and RXRs on gene transcription require a 
      highly coordinated interaction with a large number of coactivators and 
      corepressors. This review focuses on our current understanding of these 
      coregulators known to act in concert with RARs and RXRs. The mechanisms of action 
      of these coregulators are beginning to be uncovered and include the modification 
      of chromatin and the recruitment of basal transcription factors. Challenges 
      remain to understand the specificity of action of RARs and RXRs and the formation 
      of specific transcription complexes consisting of the receptors, coregulators, 
      and other unknown factors.
FAU - Wei, Li-Na
AU  - Wei LN
AD  - Department of Pharmacology, University of Minnesota Medical School, Minneapolis, 
      Minnesota 55455, USA. weixx009@tc.umn.edu
LA  - eng
GR  - DA11190/DA/NIDA NIH HHS/United States
GR  - DA11806/DA/NIDA NIH HHS/United States
GR  - DA13926/DA/NIDA NIH HHS/United States
GR  - DK54733/DK/NIDDK NIH HHS/United States
GR  - DK60521/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
DEP - 20020110
PL  - United States
TA  - Annu Rev Pharmacol Toxicol
JT  - Annual review of pharmacology and toxicology
JID - 7607088
RN  - 0 (Receptors, Retinoic Acid)
SB  - IM
MH  - Animals
MH  - *Gene Expression Regulation
MH  - Humans
MH  - Receptors, Retinoic Acid/*genetics
MH  - Signal Transduction
MH  - *Transcription, Genetic
RF  - 144
EDAT- 2002/07/27 10:00
MHDA- 2003/09/10 05:00
CRDT- 2002/07/27 10:00
PHST- 2002/07/27 10:00 [pubmed]
PHST- 2003/09/10 05:00 [medline]
PHST- 2002/07/27 10:00 [entrez]
AID - 100901.140301 [pii]
AID - 10.1146/annurev.pharmtox.43.100901.140301 [doi]
PST - ppublish
SO  - Annu Rev Pharmacol Toxicol. 2003;43:47-72. doi: 
      10.1146/annurev.pharmtox.43.100901.140301. Epub 2002 Jan 10.