PMID- 12143309
OWN - NLM
STAT- MEDLINE
DCOM- 20020813
LR  - 20061115
IS  - 0379-4172 (Print)
IS  - 0379-4172 (Linking)
VI  - 29
IP  - 7
DP  - 2002 Jul
TI  - [Detection of quantitative trait loci for growth in large white x Meishan 
      intercross].
PG  - 607-11
AB  - The development of molecular biology techniques and the application of these 
      techniques to farm animals have progressed rapidly and have opened new vistas for 
      investigators wishing to identify genes that control quantitative traits. Now 
      that a comprehensive map has been developed for the porcine genome, genomic scans 
      to detect quantitative trait loci (QTL) can begin. In order to locate the genetic 
      regions in the swine genome that are responsible for economically important 
      traits, a resource population was developed by intercross with three Large White 
      and seven Meishan pigs. In subsequent generations, 66 F2 offsprings in 2000 were 
      recorded for four growth traits including birth weight (BWT), body weight at 60 
      day (WT60), average daily gain from birth to 60 day (ADG1) and average daily gain 
      from 60 day to the end of test (ADG2), and genotyped for 48 microsatellite 
      markers spanning six chromosomes. Association analyses were performed using 
      interval mapping by regression under an outbred line-cross model on chromosomes 
      1, 2, 3, 4, 6 and 7. The F threshold values were determined by permutation. A 
      total of 12 QTL were detected at suggestive level for the four traits evaluated 
      in this study. Of the 12 suggestive QTL, 3 and 1 QTL were significant at the 
      chromosome-wise and genome-wise levels. There was a QTL for ADG2 at genome-wide 
      level on chromosome 4 explained additive variance 2.19%. A chromosome-wide QTL 
      affecting ADG1 and WT60 were detected on chromosomes 2 and 1 explained additive 
      variance 0.01% and 26.01%, respectively.
FAU - Su, Yu-Hong
AU  - Su YH
AD  - College of Animal Science and Veterinary Medicine, Huazhong Agricultural 
      University, Wuhan 430070, China. yuhongsu652@163.net
FAU - Xiong, Yuan-Zhu
AU  - Xiong YZ
FAU - Zhang, Qin
AU  - Zhang Q
FAU - Jiang, Si-Wen
AU  - Jiang SW
FAU - Yu, Li
AU  - Yu L
FAU - Lei, Ming-Gang
AU  - Lei MG
FAU - Zheng, Rong
AU  - Zheng R
FAU - Deng, Chang-Yan
AU  - Deng CY
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Yi Chuan Xue Bao
JT  - Yi chuan xue bao = Acta genetica Sinica
JID - 7900784
SB  - IM
MH  - Animals
MH  - *Chromosome Mapping
MH  - *Crosses, Genetic
MH  - Growth
MH  - *Quantitative Trait, Heritable
MH  - Swine/*genetics
EDAT- 2002/07/30 10:00
MHDA- 2002/08/14 10:01
CRDT- 2002/07/30 10:00
PHST- 2002/07/30 10:00 [pubmed]
PHST- 2002/08/14 10:01 [medline]
PHST- 2002/07/30 10:00 [entrez]
PST - ppublish
SO  - Yi Chuan Xue Bao. 2002 Jul;29(7):607-11.