PMID- 12144625
OWN - NLM
STAT- MEDLINE
DCOM- 20030303
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 59
IP  - 5
DP  - 2002 May
TI  - Analysis of HLA in children with gelatin allergy.
PG  - 412-6
AB  - Systemic immediate reactions including anaphylaxis to gelatin in vaccines have 
      been reported. However, the number of such reports is very small compared with 
      the number of children exposed to gelatin. The present study was designed to 
      investigate whether susceptibility or resistance to gelatin allergy is associated 
      with human leukocyte antigen (HLA) class II gene. Blood samples were obtained 
      from 49 patients with gelatin allergy and specific IgE to gelatin. DNA-based HLA 
      class II typing was performed to determine the DRB1, DQB1 and DPB1 alleles. 
      Genotype frequencies were compared with those found in 240 unrelated controls. 
      The frequency of DQB1*0303 (55.1%) was significantly higher in the patients than 
      in the control subjects (32.1%). The frequency of DPB1*0402 was also 
      significantly higher in the patients (32.7%) than in the control subjects 
      (15.4%). On the other hand, the frequency of subjects carrying DRB1*15 (DRB1*1501 
      and DRB1*1502) was significantly lower among the patients group (18.4%) than 
      among the controls (40.8%). We found that DQB1*0303 and DPB1*0402 were positively 
      associated with the IgE response for gelatin, while DRB1*15 was negatively 
      associated with it.
FAU - Sakaguchi, M
AU  - Sakaguchi M
AD  - Department of Immunology, National Institute of Infectious Diseases, Tokyo, 
      Japan. msakaguc@nih.go.jp
FAU - Nakayama, T
AU  - Nakayama T
FAU - Kaku, H
AU  - Kaku H
FAU - Taniguchi, K
AU  - Taniguchi K
FAU - Saito, S
AU  - Saito S
FAU - Kimura, A
AU  - Kimura A
FAU - Inouye, S
AU  - Inouye S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-DP Antigens)
RN  - 0 (HLA-DP beta-Chains)
RN  - 0 (HLA-DPB1 antigen)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DQ beta-Chains)
RN  - 0 (HLA-DQB1 antigen)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Vaccines)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 9000-70-8 (Gelatin)
SB  - IM
MH  - Child
MH  - Gelatin/*immunology
MH  - Gene Frequency
MH  - HLA-DP Antigens/genetics
MH  - HLA-DP beta-Chains
MH  - HLA-DQ Antigens/genetics
MH  - HLA-DQ beta-Chains
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - *Histocompatibility Testing
MH  - Humans
MH  - Hypersensitivity/*genetics/*immunology
MH  - Immunoglobulin E/immunology
MH  - Vaccines/immunology
EDAT- 2002/07/30 10:00
MHDA- 2003/03/04 04:00
CRDT- 2002/07/30 10:00
PHST- 2002/07/30 10:00 [pubmed]
PHST- 2003/03/04 04:00 [medline]
PHST- 2002/07/30 10:00 [entrez]
AID - tan590508 [pii]
AID - 10.1034/j.1399-0039.2002.590508.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2002 May;59(5):412-6. doi: 10.1034/j.1399-0039.2002.590508.x.