PMID- 12147313
OWN - NLM
STAT- MEDLINE
DCOM- 20021028
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 328
IP  - 3
DP  - 2002 Aug 16
TI  - Unfractionated heparin is associated with a lower rise of serum vascular cell 
      adhesion molecule-1 in acute ischemic stroke patients.
PG  - 229-32
AB  - We sought to assess the anti-inflammatory properties of unfractionated heparin 
      (UFH) in patients with ischemic stroke treated within 24 h from the onset of 
      symptoms. We studied prospectively 167 patients that received 1000 IU/h 
      intravenous UFH (n=70) or 300 mg oral aspirin (n=97) at a mean treatment delay of 
      6.7 h. Repeated plasma levels of interleukin (IL)-6, IL-10, IL-4, tumor necrosis 
      factor (TNF)-alpha, soluble intercellular adhesion molecule-1 (sICAM-1), and 
      soluble vascular cell adhesion molecule-1 (sVCAM-1) were compared in both groups 
      using multivariate analyses. Whereas TNF-alpha and sICAM-1 decreased at 48 h, 
      IL-6, IL-4, and sVCAM-1 increased compared with baseline values (P<0.01). The 
      rise of sVCAM-1 levels at 48 h was significantly lower in patients treated with 
      UFH (P=0.017) and a two-fold increase of baseline sVCAM-1 was an independent 
      predictor of poor outcome (odds ratio, 2.19, 1.1-4.39). These results suggest 
      that adjusted high-dose UFH has anti-inflammatory effects which might improve 
      recovery if administered early after stroke onset.
FAU - Chamorro, Angel
AU  - Chamorro A
AD  - Neurology Service, Hospital Clinic Universitari, 170 Villarroel, 08036, 
      Barcelona, Spain. chamorro@medicina.ub.es
FAU - Cervera, Alvaro
AU  - Cervera A
FAU - Castillo, Jose
AU  - Castillo J
FAU - Davalos, Antonio
AU  - Davalos A
FAU - Aponte, John J
AU  - Aponte JJ
FAU - Planas, Ana M
AU  - Planas AM
LA  - eng
PT  - Clinical Trial
PT  - Comparative Study
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Anticoagulants)
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 9005-49-6 (Heparin)
RN  - R16CO5Y76E (Aspirin)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Anticoagulants/chemistry/*therapeutic use
MH  - Aspirin/therapeutic use
MH  - Brain Ischemia/*blood/*drug therapy
MH  - Female
MH  - Forecasting
MH  - Heparin/chemistry/*therapeutic use
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - Prospective Studies
MH  - Single-Blind Method
MH  - Stroke/*blood/*drug therapy
MH  - Treatment Outcome
MH  - Vascular Cell Adhesion Molecule-1/*blood
EDAT- 2002/07/31 10:00
MHDA- 2002/10/29 04:00
CRDT- 2002/07/31 10:00
PHST- 2002/07/31 10:00 [pubmed]
PHST- 2002/10/29 04:00 [medline]
PHST- 2002/07/31 10:00 [entrez]
AID - S0304394002005189 [pii]
AID - 10.1016/s0304-3940(02)00518-9 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Aug 16;328(3):229-32. doi: 10.1016/s0304-3940(02)00518-9.