PMID- 12148593
OWN - NLM
STAT- MEDLINE
DCOM- 20030130
LR  - 20190922
IS  - 0271-9142 (Print)
IS  - 0271-9142 (Linking)
VI  - 22
IP  - 4
DP  - 2002 Jul
TI  - A decision between life and death during TNF-alpha-induced signaling.
PG  - 185-94
AB  - Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, exerts its 
      biological activity by signaling via its two receptors, TNF-RI and TNF-RII, and 
      by activating NF-kappaB. NF-kappaB is essential for survival of many cell types; 
      however, TNF-alpha also induces cell death. In this article, both the survival 
      and cell death signaling by TNF-alpha and the role of caspases in turning off 
      NF-kappaB survival signal are reviewed. Furthermore, a role of DAP kinase in 
      TNF-induced apoptosis is discussed. Finally, the molecular basis of the effect of 
      age on TNF-alpha-induced apoptosis in human T cells is reviewed.
FAU - Gupta, Sudhir
AU  - Gupta S
AD  - Division of Basic and Clinical Immunology, University of California, Irvine 
      92697, USA. sgupta@uci.edu
LA  - eng
GR  - AG-18313/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Netherlands
TA  - J Clin Immunol
JT  - Journal of clinical immunology
JID - 8102137
RN  - 0 (Antigens, CD)
RN  - 0 (Apoptosis Regulatory Proteins)
RN  - 0 (NF-kappa B)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type I)
RN  - 0 (Receptors, Tumor Necrosis Factor, Type II)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 2.7.11.1 (Death-Associated Protein Kinases)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Aging/immunology
MH  - Antigens, CD/metabolism
MH  - Apoptosis/*immunology/physiology
MH  - Apoptosis Regulatory Proteins
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - Caspases/metabolism
MH  - Cell Survival/*immunology/physiology
MH  - Death-Associated Protein Kinases
MH  - Humans
MH  - Mitochondria/immunology/metabolism
MH  - Models, Immunological
MH  - NF-kappa B/metabolism
MH  - Receptors, Tumor Necrosis Factor/metabolism
MH  - Receptors, Tumor Necrosis Factor, Type I
MH  - Receptors, Tumor Necrosis Factor, Type II
MH  - Signal Transduction
MH  - Tumor Necrosis Factor-alpha/*metabolism
RF  - 111
EDAT- 2002/08/01 10:00
MHDA- 2003/01/31 04:00
CRDT- 2002/08/01 10:00
PHST- 2002/08/01 10:00 [pubmed]
PHST- 2003/01/31 04:00 [medline]
PHST- 2002/08/01 10:00 [entrez]
AID - 10.1023/a:1016089607548 [doi]
PST - ppublish
SO  - J Clin Immunol. 2002 Jul;22(4):185-94. doi: 10.1023/a:1016089607548.