PMID- 12150380
OWN - NLM
STAT- MEDLINE
DCOM- 20030123
LR  - 20220331
IS  - 0892-1997 (Print)
IS  - 0892-1997 (Linking)
VI  - 16
IP  - 2
DP  - 2002 Jun
TI  - Validity and reliability of the reflux symptom index (RSI).
PG  - 274-7
AB  - Laryngopharyngeal reflux (LPR) is present in up to 50% of patients with voice 
      disorders. Currently, there is no validated instrument that documents symptom 
      severity in LPR. We developed the reflux symptom index (RSI), a self-administered 
      nine-item outcomes instrument for LPR. The purpose of this investigation was to 
      evaluate the psychometric properties of the RSI. For validity assessment, 25 
      patients with LPR were evaluated prospectively before and six months after b.i.d. 
      treatment with proton pump inhibitors (PPI). Each patient completed the RSI as 
      well as the 30-item voice handicap index (VHI). For reliability assessment, the 
      study patients were given the RSI on two separate occasions before the initiation 
      of treatment. Normative RSI data were derived from 25 age-matched and 
      gender-matched controls taken from an existing database of asymptomatic 
      individuals without any evidence of LPR. The mean RSI (+/- standard deviation) of 
      patients with LPR improved from 21.2 (+/- 10.7) to 12.8 (+/- 10.0), and the mean 
      VHI improved from 52.2 (+/- 24.7) to 41.5 (+/- 25.0) after 6 months of therapy (p 
      = 0.001 and 0.065, respectively). Of the three VHI subscales (emotional, 
      physical, functional), only the functional subscale improved significantly (p = 
      0.037). Patients who experienced a five point or better improvement in RSI were 
      11 times more likely to experience a five-point improvement in VHI (95% 
      confidence interval = 1.7, 76.8). For reliability assessment, the first and 
      second pretreatment RSIs were 19.9 (+/- 11.1) and 20.9 (+/- 9.6), respectively 
      (correlation coefficient = 0.81, p < 0.001). The single-item correlation 
      coefficients ranged from 0.41 to 0.91 (p < 0.05 for all items). The mean 
      pretreatment RSI in patients with LPR was significantly higher than controls 
      (21.2 versus 11.6; p < 0.001). The mean RSI of patients with LPR after 6 months 
      of PPI therapy approached that of asymptomatic controls (p > 0.05). The RSI is 
      easily administered, highly reproducible, and exhibits excellent construct and 
      criterion-based validity.
FAU - Belafsky, Peter C
AU  - Belafsky PC
AD  - Center for Voice Disorders of Wake Forest University, Winston-Salem, North 
      Carolina 27157-1034, USA.
FAU - Postma, Gregory N
AU  - Postma GN
FAU - Koufman, James A
AU  - Koufman JA
LA  - eng
PT  - Journal Article
PT  - Validation Study
PL  - United States
TA  - J Voice
JT  - Journal of voice : official journal of the Voice Foundation
JID - 8712262
RN  - 0 (Proton Pumps)
SB  - IM
MH  - Adult
MH  - Female
MH  - Gastroesophageal Reflux/complications/*diagnosis/therapy
MH  - Humans
MH  - Male
MH  - Prospective Studies
MH  - Proton Pumps/therapeutic use
MH  - Quality of Life
MH  - Reproducibility of Results
MH  - Severity of Illness Index
MH  - Voice Disorders/diagnosis/etiology
EDAT- 2002/08/02 10:00
MHDA- 2003/01/24 04:00
CRDT- 2002/08/02 10:00
PHST- 2002/08/02 10:00 [pubmed]
PHST- 2003/01/24 04:00 [medline]
PHST- 2002/08/02 10:00 [entrez]
AID - S0892-1997(02)00097-8 [pii]
AID - 10.1016/s0892-1997(02)00097-8 [doi]
PST - ppublish
SO  - J Voice. 2002 Jun;16(2):274-7. doi: 10.1016/s0892-1997(02)00097-8.