PMID- 12151080
OWN - NLM
STAT- MEDLINE
DCOM- 20030204
LR  - 20190906
IS  - 8756-3282 (Print)
IS  - 1873-2763 (Linking)
VI  - 31
IP  - 2
DP  - 2002 Aug
TI  - Developmentally regulated monocyte recruitment and bone resorption are modulated 
      by functional deletion of the monocytic chemoattractant protein-1 gene.
PG  - 282-7
AB  - Tooth eruption involves the movement of a tooth from its site of development 
      within the alveolar bone to its functional position in the oral cavity. Because 
      this process is dependent upon monocytes and formation of osteoclasts, it 
      represents an excellent model for examination of these processes under 
      developmental regulation. We investigated the functional role of monocyte 
      chemoattractant protein-1 (MCP-1) in monocyte recruitment and its impact on bone 
      resorption by examining each parameter in MCP-1(-/-) mice as compared with 
      wild-type controls during tooth eruption. The peak number of monocytes occurred 
      on day 5 in the MCP-1(-/-) mice and on day 9 in the wild-type mice. The peak 
      number of osteoclasts followed the same pattern, occurring sooner in the 
      MCP-1(-/-) (day 5) than in wild-type mice (day 9). Consistent with this, 
      MCP-1(-/-) mice had an accelerated rate of tooth eruption in the early phase when 
      the teeth first entered the oral cavity as compared with the wild-type mice. 
      However, there was accelerated eruption in the wild-type group in the later phase 
      of tooth eruption. When examined at the molecular level, inducible nitric oxide 
      synthase (iNOS) and interleukin-11 and -6 were expressed at considerably higher 
      levels in the experimental group with accelerated tooth eruption. This is the 
      first report identifying these factors as potential modulators of bone resorption 
      that can accelerate the rate of tooth eruption. We conclude that, at early 
      timepoints, monocyte recruitment occurs by MCP-1-independent mechanisms. However, 
      at a later timepoint, MCP-1 may play a contributory role in the recruitment of 
      monocytic cells, allowing the wild-type animals to catch up.
FAU - Graves, D T
AU  - Graves DT
AD  - Department of Periodontology and Oral Biology, Boston University School of Dental 
      Medicine, Boston, MA 02118, USA. dgraves@bsu.edu
FAU - Alsulaimani, F
AU  - Alsulaimani F
FAU - Ding, Y
AU  - Ding Y
FAU - Marks, S C Jr
AU  - Marks SC Jr
LA  - eng
GR  - DE07444/DE/NIDCR NIH HHS/United States
GR  - DE07559/DE/NIDCR NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Bone
JT  - Bone
JID - 8504048
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Bone Resorption/*genetics/*metabolism
MH  - Chemokine CCL2/*deficiency/*genetics
MH  - *Gene Deletion
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Monocytes/*metabolism
MH  - Tooth Eruption/genetics/physiology
EDAT- 2002/08/02 10:00
MHDA- 2003/02/05 04:00
CRDT- 2002/08/02 10:00
PHST- 2002/08/02 10:00 [pubmed]
PHST- 2003/02/05 04:00 [medline]
PHST- 2002/08/02 10:00 [entrez]
AID - S8756328202008293 [pii]
AID - 10.1016/s8756-3282(02)00829-3 [doi]
PST - ppublish
SO  - Bone. 2002 Aug;31(2):282-7. doi: 10.1016/s8756-3282(02)00829-3.