PMID- 12153539
OWN - NLM
STAT- MEDLINE
DCOM- 20021009
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 16
IP  - 1
DP  - 2002 Jul
TI  - BDNF attenuates hippocampal LTD via activation of phospholipase C: implications 
      for a vertical shift in the frequency-response curve of synaptic plasticity.
PG  - 145-8
AB  - Recent evidence shows that neurotrophins are not only involved in neuronal 
      survival and differentiation during development but also in modulating synaptic 
      strength in the mature brain. To understand how neurotrophins alter this synaptic 
      modification, we have investigated the effect of brain-derived neurotrophic 
      factor (BDNF) on long-term depression (LTD) at Schaffer collateral-CA1 synapses 
      in rat hippocampal slices. The slices treated with BDNF for 5 min showed 
      significantly less LTD in response to a 1-Hz tetanus compared with controls but 
      displayed normal LTD when the afferents were tetanized at 10 Hz. Because BDNF 
      enhanced long-term potentiation (LTP) induced by a 30-Hz tetanus, the synaptic 
      modification threshold (theta(m)) as defined in the 'BCM' theory of Bienenstock 
      Cooper & Monroe [Bienenstock et al. (1982), J. Neurosci., 2, 32-48] was not 
      shifted. BNDF is likely to alter the capability of the plastic changes in 
      synaptic efficacy, i.e. to produce an upward shift in the BCM curve. The 
      suppressive effect of BDNF on LTD was prevented by either the tyrosine kinase 
      (Trk) receptor inhibitor K252a or the phospholipase C inhibitor U73122. Thus, 
      TrkB activation may attenuate LTD through phospholipase C signalling pathway.
FAU - Ikegaya, Yuji
AU  - Ikegaya Y
AD  - Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, 
      The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. 
      ikegaya@tk.airnet.ne.jp
FAU - Ishizaka, Yoko
AU  - Ishizaka Y
FAU - Matsuki, Norio
AU  - Matsuki N
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.1.4.- (Type C Phospholipases)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Electric Stimulation
MH  - Hippocampus/enzymology/*metabolism/physiology
MH  - Long-Term Potentiation
MH  - *Neuronal Plasticity
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/metabolism
MH  - Synaptic Transmission
MH  - Type C Phospholipases/*metabolism
EDAT- 2002/08/03 10:00
MHDA- 2002/10/10 04:00
CRDT- 2002/08/03 10:00
PHST- 2002/08/03 10:00 [pubmed]
PHST- 2002/10/10 04:00 [medline]
PHST- 2002/08/03 10:00 [entrez]
AID - 2051 [pii]
AID - 10.1046/j.1460-9568.2002.02051.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2002 Jul;16(1):145-8. doi: 10.1046/j.1460-9568.2002.02051.x.