PMID- 12161009
OWN - NLM
STAT- MEDLINE
DCOM- 20030613
LR  - 20190813
IS  - 0303-7207 (Print)
IS  - 0303-7207 (Linking)
VI  - 193
IP  - 1-2
DP  - 2002 Jul 31
TI  - Alfa and beta estrogen receptors and the biliary tree.
PG  - 105-8
AB  - This manuscript summarizes recent data showing that estrogens and their receptors 
      play an important role in modulating cholangiocyte proliferation. We have 
      recently demonstrated that rat cholangiocytes express both estrogen receptors 
      (ER)-alpha and -beta subtypes, while hepatocytes only express ER-alpha. ER and 
      especially the ER-beta subtype, are overexpressed in cholangiocytes proliferating 
      after bile duct ligation (BDL) in the rat, in association with enlarged bile duct 
      mass and with enhanced estradiol serum levels. Cholangiocyte proliferation, 
      during BDL, is impaired by estrogen antagonists (tamoxifen, ICI 182,780) which 
      furthermore, induce the overexpression of Fas antigen and activate apoptosis of 
      proliferating cholangiocytes. 17beta-estradiol stimulates, in vitro cholangiocyte 
      proliferation, and this effect is individually blocked by tamoxifen or ICI 
      182,780. Cholangiocyte proliferation during BDL was associated with an enhanced 
      protein expression of phosphorylated extracellular regulated kinases (ERK)1/2 
      which is, in contrast, negatively modulated by tamoxifen in association with its 
      antiproliferative effect. This indicates a major involvement of the ERK system in 
      the estrogen modulation of cholangiocyte proliferation.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Alvaro, Domenico
AU  - Alvaro D
AD  - Division of Gastroenterology, Department of Clinical Medicine, University of Rome 
      'La Sapienza', Via valsolda 45/i, 00141 Rome, Italy. alvaro@axrma.uniromal.it
FAU - Alpini, G
AU  - Alpini G
FAU - Onori, P
AU  - Onori P
FAU - Franchitto, A
AU  - Franchitto A
FAU - Glaser, S S
AU  - Glaser SS
FAU - Le Sage, G
AU  - Le Sage G
FAU - Folli, F
AU  - Folli F
FAU - Attili, A F
AU  - Attili AF
FAU - Gaudio, E
AU  - Gaudio E
LA  - eng
GR  - DK58411/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Animals
MH  - Bile Ducts, Intrahepatic/chemistry/*cytology
MH  - Cell Division/drug effects
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Humans
MH  - Rats
MH  - Receptors, Estrogen/*metabolism
MH  - Signal Transduction
RF  - 23
EDAT- 2002/08/06 10:00
MHDA- 2003/06/14 05:00
CRDT- 2002/08/06 10:00
PHST- 2002/08/06 10:00 [pubmed]
PHST- 2003/06/14 05:00 [medline]
PHST- 2002/08/06 10:00 [entrez]
AID - S030372070200103X [pii]
AID - 10.1016/s0303-7207(02)00103-x [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2002 Jul 31;193(1-2):105-8. doi: 
      10.1016/s0303-7207(02)00103-x.