PMID- 12161226
OWN - NLM
STAT- MEDLINE
DCOM- 20020923
LR  - 20190623
IS  - 0002-9149 (Print)
IS  - 0002-9149 (Linking)
VI  - 90
IP  - 4
DP  - 2002 Aug 15
TI  - Effectiveness of resynchronization therapy in patients with end-stage heart 
      failure.
PG  - 379-83
AB  - Biventricular pacing has been introduced to treat patients with end-stage heart 
      failure, and short-term results of this technique are promising. Because data on 
      longer follow-up are limited to 3-month follow-up, the sustained effect of 
      biventricular pacing is unclear and long-term survival is unknown. Forty patients 
      with end-stage heart failure in New York Heart Association (NYHA) functional 
      class III or IV with left ventricular (LV) ejection fraction (EF) <35%, QRS 
      duration >120 ms, and left bundle branch block morphology received a 
      biventricular pacemaker. At baseline, and at 3 and 6 months after implantation, 
      the following parameters were evaluated: NYHA class, Minnesota quality-of-life 
      score, QRS duration on surface electrocardiogram, 6-minute walking distance, and 
      LVEF. Long-term follow-up was obtained for up to 2 years. All clinical parameters 
      improved significantly at 3 months and remained unchanged at 6-month follow-up. 
      LVEF increased from 24 +/- 9% to 34 +/- 11%. Before implantation, patients were 
      hospitalized (for congestive heart failure) an average of 3.9 +/- 5.3 days/year 
      compared with 0.5 +/- 1.5 days/year after implantation. Long-term follow-up 
      showed a survival of 87.5% at 2 years. Thus, biventricular pacing resulted in 
      improvement of symptoms and quality of life, accompanied by improvement in 
      6-minute walking distance and LVEF. These effects were observed at 3 months after 
      implantation and were maintained at 6-month follow-up. Moreover, 2-year survival 
      was excellent.
FAU - Molhoek, Sander G
AU  - Molhoek SG
AD  - Department of Cardiology, Leiden University Medical Center, Leiden, The 
      Netherlands.
FAU - Bax, Jeroen J
AU  - Bax JJ
FAU - van Erven, Lieselot
AU  - van Erven L
FAU - Bootsma, Marianne
AU  - Bootsma M
FAU - Boersma, Eric
AU  - Boersma E
FAU - Steendijk, Paul
AU  - Steendijk P
FAU - van der Wall, Ernst E
AU  - van der Wall EE
FAU - Schalij, Martin J
AU  - Schalij MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Am J Cardiol
JT  - The American journal of cardiology
JID - 0207277
SB  - IM
MH  - Cardiac Pacing, Artificial/*methods
MH  - Exercise Tolerance
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/mortality/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Quality of Life
MH  - Stroke Volume
MH  - Surveys and Questionnaires
MH  - Treatment Outcome
MH  - Ventricular Function, Left
EDAT- 2002/08/06 10:00
MHDA- 2002/09/24 06:00
CRDT- 2002/08/06 10:00
PHST- 2002/08/06 10:00 [pubmed]
PHST- 2002/09/24 06:00 [medline]
PHST- 2002/08/06 10:00 [entrez]
AID - S0002914902024931 [pii]
AID - 10.1016/s0002-9149(02)02493-1 [doi]
PST - ppublish
SO  - Am J Cardiol. 2002 Aug 15;90(4):379-83. doi: 10.1016/s0002-9149(02)02493-1.