PMID- 12161250
OWN - NLM
STAT- MEDLINE
DCOM- 20021115
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 329
IP  - 1
DP  - 2002 Aug 23
TI  - Region-specific phosphorylation of ATF-2, Elk-1 and c-Jun in rat hippocampus and 
      cerebellum after electroconvulsive shock.
PG  - 9-12
AB  - There have been reports of regional differences in the activation of mitogen 
      activated protein kinases (MAPKs) and in the induction of immediate early genes 
      after electroconvulsive shock (ECS) in the rat brain. This study was performed to 
      determine whether ECS induce the region-specific phosphorylation of 
      MAPK-downstream transcription factors, ATF-2, Elk-1, c-Jun, in rat hippocampus 
      and cerebellum. Following ECS, the phosphorylation of ATF-2 was highly increased 
      in the hippocampus but slightly in the cerebellum. The phosphorylation of Elk-1 
      was increased in the cerebellum but not in the hippocampus. In contrast, the 
      phosphorylation of c-Jun was increased only in the hippocampus. These results 
      indicate that ECS can induce the region-specific phosphorylation of 
      MAPK-downstream transcription factors in rat hippocampus and cerebellum.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Ahn, Yong Min
AU  - Ahn YM
AD  - Department of Neuropsychiatry, Eulji University School of Medicine, Seoul 
      139-711, South Korea.
FAU - Kang, Ung Gu
AU  - Kang UG
FAU - Oh, Seung Wook
AU  - Oh SW
FAU - Juhnn, Yong-Sung
AU  - Juhnn YS
FAU - Joo, Yeon-Ho
AU  - Joo YH
FAU - Park, Joo-Bae
AU  - Park JB
FAU - Kim, Yong Sik
AU  - Kim YS
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Activating Transcription Factor 2)
RN  - 0 (Atf2 protein, rat)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Elk1 protein, rat)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-jun)
RN  - 0 (Transcription Factors)
RN  - 0 (ets-Domain Protein Elk-1)
SB  - IM
MH  - Activating Transcription Factor 2
MH  - Animals
MH  - Cerebellum/*metabolism
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - *DNA-Binding Proteins
MH  - *Electroshock
MH  - Genes, Immediate-Early/physiology
MH  - Hippocampus/*metabolism
MH  - MAP Kinase Signaling System/physiology
MH  - Male
MH  - Phosphorylation
MH  - Proto-Oncogene Proteins/*metabolism
MH  - Proto-Oncogene Proteins c-jun/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Transcription Factors/*metabolism
MH  - ets-Domain Protein Elk-1
EDAT- 2002/08/06 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/08/06 10:00
PHST- 2002/08/06 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/08/06 10:00 [entrez]
AID - S0304394002005682 [pii]
AID - 10.1016/s0304-3940(02)00568-2 [doi]
PST - ppublish
SO  - Neurosci Lett. 2002 Aug 23;329(1):9-12. doi: 10.1016/s0304-3940(02)00568-2.