PMID- 12161944
OWN - NLM
STAT- MEDLINE
DCOM- 20021112
LR  - 20191210
IS  - 1124-3562 (Print)
IS  - 1124-3562 (Linking)
VI  - 74
IP  - 2
DP  - 2002 Jun
TI  - Decrease of ultrasound estimated bladder weight during tamsulosin treatment in 
      patients with benign prostatic enlargement.
PG  - 90-4
AB  - OBJECTIVE: The noninvasive method for estimating bladder weight (UEBW, Ultrasound 
      Estimated Bladder Weight) can be used as a measure of bladder hypertrophy and may 
      have clinical use for evaluating intravesical obstruction in male patients. The 
      aim of this study was to assess whether, in patients with bladder outlet 
      obstruction (BOO), tamsulosin treatment produced any significant change in UEBW. 
      METHODS: 32 male patients with lower urinary tract symptoms (LUTS) suggestive of 
      BOO [benign prostatic hyperflesia (BPH) was the apparent cause of BOO] were 
      enrolled in an open pilot study. At baseline, physical examination, ECG, 
      hematochemical tests, urine analysis, urine culture, urodynamics, 
      urethrocystography, transrectal ultrasound, UEBW and symptom score were 
      performed. Using the International Continence Society (ICS) nomogram, patients 
      were assigned to three different groups: obstructed, not obstructed and 
      equivocal. Only patients in the obstructed and equivocal categories were treated 
      with tamsulosin 0.4 mg once daily for 6 months. Follow-up for all patients took 
      place after 30 days, 3 and 6 months of treatment. RESULTS: In the obstructed 
      group of patients, the decrease in UEBW was observed at 30 days and maintained up 
      to 6 months, with a significantly improved Qmax. A statistically significant 
      correlation was found between UEBW and postvoid residual urine (PVR) and 
      Abrams-Griffith number (AG). CONCLUSIONS: The results of this study suggest a 
      significant change in UEBW during tamsulosin treatment. The change observed might 
      be suggestive of a therapeutic effect of tamsulosin on the detrusor muscle. 
      Further and more extensive studies are needed in order to confirm a possible 
      therapeutic effect of tamsulosin on the detrusor muscle.
FAU - Sironi, Dario
AU  - Sironi D
AD  - Divisione di Urologia, Ospedali Riuniti di Bergamo, Bergamo, Italy. 
      dariosironi@virgilio.it
FAU - Levorato, Carlo Alberto
AU  - Levorato CA
FAU - Deiana, Gianfranco
AU  - Deiana G
FAU - Borgonovo, Giulio
AU  - Borgonovo G
FAU - Belussi, Domenico
AU  - Belussi D
FAU - Ranieri, Antonio
AU  - Ranieri A
FAU - Lembo, Antonio
AU  - Lembo A
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PL  - Italy
TA  - Arch Ital Urol Androl
JT  - Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa 
      italiana di ecografia urologica e nefrologica
JID - 9308247
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Sulfonamides)
RN  - G3P28OML5I (Tamsulosin)
SB  - IM
MH  - Adrenergic alpha-Antagonists/pharmacology/*therapeutic use
MH  - Aged
MH  - Anthropometry/methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Muscle, Smooth/diagnostic imaging/drug effects/pathology
MH  - Organ Size
MH  - Pilot Projects
MH  - Prostatic Hyperplasia/complications/diagnostic imaging/*drug therapy
MH  - Sulfonamides/pharmacology/*therapeutic use
MH  - Tamsulosin
MH  - Ultrasonography
MH  - Urinary Bladder/diagnostic imaging/*pathology
MH  - Urinary Bladder Neck Obstruction/diagnostic imaging/etiology
EDAT- 2002/08/07 10:00
MHDA- 2002/11/26 04:00
CRDT- 2002/08/07 10:00
PHST- 2002/08/07 10:00 [pubmed]
PHST- 2002/11/26 04:00 [medline]
PHST- 2002/08/07 10:00 [entrez]
PST - ppublish
SO  - Arch Ital Urol Androl. 2002 Jun;74(2):90-4.