PMID- 12162435
OWN - NLM
STAT- MEDLINE
DCOM- 20030214
LR  - 20190818
IS  - 0300-8177 (Print)
IS  - 0300-8177 (Linking)
VI  - 234-235
IP  - 1-2
DP  - 2002 May-Jun
TI  - Tumor necrosis factor-alpha gene promoter polymorphism in coal workers' 
      pneumoconiosis.
PG  - 205-9
AB  - Tumor necrosis factor-alpha (TNF-alpha) is believed to play a central role in the 
      pathogenesis of pneumoconiosis. TNF2, a polymorphism in the TNF-a gene promoter, 
      has been associated with an increase in TNF-alpha production and airway 
      inflammation. To investigate the frequency of TNF2 in patients who have coal 
      workers' pneumoconiosis (CWP) and to determine whether it is associated with 
      development of a large opacity in CWP, we investigated the expression ofthe TNF2 
      allele in 80 patients who had CWP and in 54 healthy controls using restriction 
      fragment length polymorphism (RFLP). Compared to controls (10.2%), the frequency 
      of the TNF2 allele was greater in the CWP patients (20.6%). Furthermore, the TNF2 
      allele was very common in patients who had a large opacity (28.2%) in comparison 
      with 13.4% in those with simpleCWP. From these data, we suggest that the TNF2 
      allele is associated with the development of a large opacity in CWP.
FAU - Kim, Kyoung Ah
AU  - Kim KA
AD  - Department of Occupational and Environmental Medicine, St Mary's Hospital, The 
      Catholic University of Korea, Youngdunpo-gu, Seoul.
FAU - Cho, Yong-Yeun
AU  - Cho YY
FAU - Cho, Jung Sik
AU  - Cho JS
FAU - Yang, Ki Hwa
AU  - Yang KH
FAU - Lee, Woon Kyu
AU  - Lee WK
FAU - Lee, Kweon-Haeng
AU  - Lee KH
FAU - Kim, Yun Shin
AU  - Kim YS
FAU - Lim, Young
AU  - Lim Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
RN  - 0 (Coal)
RN  - 0 (Dust)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Coal
MH  - *Coal Mining
MH  - Dust
MH  - Gene Frequency/genetics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Monocytes/metabolism
MH  - Occupational Diseases/genetics
MH  - Pneumoconiosis/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Polymorphism, Restriction Fragment Length
MH  - Promoter Regions, Genetic/*genetics
MH  - Smoking
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/*genetics/metabolism
EDAT- 2002/08/07 10:00
MHDA- 2003/02/15 04:00
CRDT- 2002/08/07 10:00
PHST- 2002/08/07 10:00 [pubmed]
PHST- 2003/02/15 04:00 [medline]
PHST- 2002/08/07 10:00 [entrez]
AID - 10.1023/a:1015914409661 [doi]
PST - ppublish
SO  - Mol Cell Biochem. 2002 May-Jun;234-235(1-2):205-9. doi: 10.1023/a:1015914409661.