PMID- 12162874
OWN - NLM
STAT- MEDLINE
DCOM- 20030312
LR  - 20081121
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 22
IP  - 6
DP  - 2002 Jun
TI  - Herpes simplex virus type 1 infection induces upregulation of interleukin-23 
      (p19) mRNA expression in trigeminal ganglia of BALB/c mice.
PG  - 641-51
AB  - We investigated the expression kinetics of several cytokines in trigeminal 
      ganglia (TG) and in brains of BALB/c mice during the course of ocular herpes 
      simplex virus type 1 (HSV-1) infection. All mice recovered from the infection 
      within 2 weeks. The quantitative rapid real-time RT-PCR method was used to 
      analyze interleukin-4 (IL-4), interferon-gamma (IFN-gamma), IL-12p35, IL-12p40, 
      and the recently described IL-23 (p19) mRNA in TG, brain, and splenocyte samples. 
      In TG, we found elevated expression of mRNA for IL-23 (p19) from early acute 
      infection (day 3) to the beginning of the latent phase (day 14). The increase was 
      not detected in brain or in the spleen. IL-4 expression occurred in both TG and 
      brain from the beginning of the experiment to the latent phase. During the latent 
      phase (days 14 and 31), IL-4 expression was significantly elevated in the brain 
      when compared with the uninfected controls (p < 0.05). Considerable expression of 
      IFN-gamma mRNA was detected in TG of mice during acute HSV-1 infection. The 
      expression of IL-23 was detected also in the brains of the mice, even though no 
      significant changes were found during the acute HSV-1 infection. This is, to our 
      knowledge, the first report to show elevated expression of IL-23 (p19) mRNA (p < 
      0.05) during viral infection in TG of mice.
FAU - Broberg, Eeva K
AU  - Broberg EK
AD  - Department of Virology, the MediCity Research Laboratory, and the Turku Graduate 
      School of Biomedical Sciences, University of Turku, FIN-20520 Turku, Finland. 
      eeva.broberg@utu.fi
FAU - Setala, Niko
AU  - Setala N
FAU - Eralinna, Juha-Pekka
AU  - Eralinna JP
FAU - Salmi, Aimo A
AU  - Salmi AA
FAU - Roytta, Matias
AU  - Roytta M
FAU - Hukkanen, Veijo
AU  - Hukkanen V
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Il23a protein, mouse)
RN  - 0 (Interleukin-12 Subunit p35)
RN  - 0 (Interleukin-12 Subunit p40)
RN  - 0 (Interleukin-23)
RN  - 0 (Interleukin-23 Subunit p19)
RN  - 0 (Interleukins)
RN  - 0 (Protein Subunits)
RN  - 0 (RNA, Messenger)
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Brain/metabolism/virology
MH  - Chick Embryo
MH  - Eye/metabolism/virology
MH  - Female
MH  - Herpes Simplex/genetics/*metabolism
MH  - Interferon-gamma/metabolism
MH  - Interleukin-12/metabolism
MH  - Interleukin-12 Subunit p35
MH  - Interleukin-12 Subunit p40
MH  - Interleukin-23
MH  - Interleukin-23 Subunit p19
MH  - Interleukin-4/metabolism
MH  - Interleukins/genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Protein Subunits/metabolism
MH  - RNA, Messenger/metabolism
MH  - Trigeminal Ganglion/*metabolism/virology
MH  - *Up-Regulation
EDAT- 2002/08/07 10:00
MHDA- 2003/03/13 04:00
CRDT- 2002/08/07 10:00
PHST- 2002/08/07 10:00 [pubmed]
PHST- 2003/03/13 04:00 [medline]
PHST- 2002/08/07 10:00 [entrez]
AID - 10.1089/10799900260100123 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2002 Jun;22(6):641-51. doi: 10.1089/10799900260100123.