PMID- 12162875
OWN - NLM
STAT- MEDLINE
DCOM- 20030312
LR  - 20181130
IS  - 1079-9907 (Print)
IS  - 1079-9907 (Linking)
VI  - 22
IP  - 6
DP  - 2002 Jun
TI  - Type I interferon production by plasmacytoid dendritic cells and monocytes is 
      triggered by viruses, but the level of production is controlled by distinct 
      cytokines.
PG  - 653-9
AB  - The principal interferon-alpha/beta (IFN-I)-producing cells are plasmacytoid 
      dendritic cell (PDC) precursors belonging to the lymphoid lineage. Monocytes that 
      can differentiate into dendritic cells (DC) also produce IFN-I, although much 
      less than PDC, after interaction with infectious agents. We show that whereas 
      viruses trigger these cells to produce IFN-I, the amount of IFN is tightly 
      controlled by cytokines. Monocytes produced IFN-I in response to Sendai virus 
      (SV) infection, and PDC responded to both SV and herpes simplex virus (HSV). All 
      cytokines tested failed to induce production of IFN-I in the absence of 
      infection. However, among 18 relevant cytokines, incubation of PDC with 
      interleukin-4 (IL-4), IL-15, and IL-7 alone or in combination with IL-3 before 
      infection, enhanced IFN-I secretion. At variance, IL-12 alone or in synergy with 
      granulocyte-macrophage colony-stimulating factor (GM-CSF) was active on 
      SV-infected but not on HSV-infected monocytes. Tumor necrosis factor-alpha 
      (TNF-alpha) and IL-4 inhibited IFN-I production by PDC and monocytes, 
      respectively, and IL-10 strongly inhibited IFN-I production in both cell 
      lineages. The response of PDC to IL-7 and IL-15, which also activate natural 
      killer (NK) cell maturation, further emphasizes the cooperation between these two 
      cell subsets in the control of innate immunity.
FAU - Gary-Gouy, Helene
AU  - Gary-Gouy H
AD  - Laboratoire d'Immunologie, INSERM U 543, Hopital Pitie-Salpetriere, Universite de 
      Paris VI, 75013 Paris, France.
FAU - Lebon, Pierre
AU  - Lebon P
FAU - Dalloul, Ali H
AU  - Dalloul AH
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Interferon Cytokine Res
JT  - Journal of interferon & cytokine research : the official journal of the 
      International Society for Interferon and Cytokine Research
JID - 9507088
RN  - 0 (Cytokines)
RN  - 0 (Drug Combinations)
RN  - 0 (Interferon Type I)
RN  - 0 (Interleukin-15)
RN  - 0 (Interleukin-3)
RN  - 0 (Interleukin-7)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 130068-27-8 (Interleukin-10)
RN  - 187348-17-0 (Interleukin-12)
RN  - 207137-56-2 (Interleukin-4)
RN  - 83869-56-1 (Granulocyte-Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Cells, Cultured
MH  - Cytokines/*pharmacology
MH  - Dendritic Cells/drug effects/*metabolism/virology
MH  - Drug Combinations
MH  - Drug Synergism
MH  - Granulocyte-Macrophage Colony-Stimulating Factor/pharmacology
MH  - Herpes Simplex/*immunology
MH  - Humans
MH  - Interferon Type I/*biosynthesis/metabolism
MH  - Interleukin-10/pharmacology
MH  - Interleukin-12/pharmacology
MH  - Interleukin-15/pharmacology
MH  - Interleukin-3/pharmacology
MH  - Interleukin-4/pharmacology
MH  - Interleukin-7/pharmacology
MH  - Monocytes/drug effects/*metabolism/virology
MH  - Parainfluenza Virus 1, Human/*immunology
MH  - Recombinant Proteins/pharmacology
MH  - Tumor Necrosis Factor-alpha/pharmacology
EDAT- 2002/08/07 10:00
MHDA- 2003/03/13 04:00
CRDT- 2002/08/07 10:00
PHST- 2002/08/07 10:00 [pubmed]
PHST- 2003/03/13 04:00 [medline]
PHST- 2002/08/07 10:00 [entrez]
AID - 10.1089/10799900260100132 [doi]
PST - ppublish
SO  - J Interferon Cytokine Res. 2002 Jun;22(6):653-9. doi: 10.1089/10799900260100132.