PMID- 12165115
OWN - NLM
STAT- MEDLINE
DCOM- 20030131
LR  - 20131121
IS  - 1050-7256 (Print)
IS  - 1050-7256 (Linking)
VI  - 12
IP  - 6
DP  - 2002 Jun
TI  - Thyroid hormone metabolism in patients with congestive heart failure: the low 
      triiodothyronine state.
PG  - 511-5
AB  - Thyroid hormone has multiple effects on the cardiovascular system, ranging from 
      molecular and cellular effects to the consequent hemodynamic alterations. 
      Consequently, thyroid function has been evaluated in small cohorts of patients 
      with advanced heart failure that indicate a significant prevalence of morphologic 
      or functional thyroid disorders. We sought to determine the prevalence of altered 
      thyroid hormone metabolism in a broad spectrum of ambulatory heart failure 
      patients. Thyroid function tests were evaluated in 132 ambulatory patients (98 
      males, 32 females, mean age, 67 years) with left ventricular systolic dysfunction 
      (EF < 35%) and New York Heart Association (NYHA) class I-IV symptoms. 
      Hypothyroidism was defined as serum thyroid-stimulating hormone (TSH) > 4.25 U/mL 
      and low triiodothyronine (T3) state was defined as T3 levels < 80 ng/dL, with 
      normal thyroxine (T4) and TSH level. Seven percent of patients were found to have 
      primary hypothyroidism and 34% have a low T3 state. Of patients receiving 
      amiodarone, 21% had elevated TSH levels and 76% had low T3 levels. The prevalence 
      of abnormal thyroid function correlated with NYHA class. There is an unexpectedly 
      high risk of hypothyroidism and low T3 syndrome in patients regardless of 
      treatment with amiodarone, which appears to correlate with disease severity that 
      requires further investigation.
FAU - Ascheim, Deborah D
AU  - Ascheim DD
AD  - Division of Circulatory Physiology, Department of Medicine, Columbia University 
      College of Physicians & Surgeons, New York, New York 10032, USA. 
      dda18@columbia.edu
FAU - Hryniewicz, Katarzyna
AU  - Hryniewicz K
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Thyroid
JT  - Thyroid : official journal of the American Thyroid Association
JID - 9104317
RN  - 0 (Thyroid Hormones)
RN  - 06LU7C9H1V (Triiodothyronine)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Heart Failure/*blood/complications/diagnosis
MH  - Humans
MH  - Hypothyroidism/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Prevalence
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Thyroid Hormones/*blood/*metabolism
MH  - Triiodothyronine/blood/*deficiency
MH  - Ventricular Dysfunction, Left
RF  - 29
EDAT- 2002/08/08 10:00
MHDA- 2003/02/01 04:00
CRDT- 2002/08/08 10:00
PHST- 2002/08/08 10:00 [pubmed]
PHST- 2003/02/01 04:00 [medline]
PHST- 2002/08/08 10:00 [entrez]
AID - 10.1089/105072502760143908 [doi]
PST - ppublish
SO  - Thyroid. 2002 Jun;12(6):511-5. doi: 10.1089/105072502760143908.