PMID- 12165447
OWN - NLM
STAT- MEDLINE
DCOM- 20020820
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 136
IP  - 1
DP  - 2002 Jul 1
TI  - Clinical significance of allelic loss of chromosome region 5q22.3 approximately 
      q23.2 in nonpapillary renal cell carcinoma.
PG  - 23-30
AB  - To analyze the clinical significance of copy number gain and loss at chromosome 
      region 5q21 approximately q23, 105 nonpapillary renal cell carcinomas (RCC) were 
      examined by interphase cytogenetic analysis using the dual-color fluorescence in 
      situ hybridization (FISH) technique. DNA probes for D5S23 (5p15.2), cCI5-243 
      (5q21.2 approximately q21.3), and cCI5-215 (5q22.3 approximately q23.2) were 
      used, and the signals for cCI5-243 and cCI5-215 were compared with those for 
      D5S23 as the numerical control. Aneusomy (three or more copies) of chromosome 5 
      was found in 22 tumors (21.0%). Aneusomy was significantly correlated with loss 
      at 5q21 approximately q23, while disomy with gain at 5q21 approximately q23 
      (P<0.05). Aneusomy was also significantly related to poor disease-specific 
      survival (P<0.01). Gain and loss at cCI5-243 were seen in 34 (32.4%) and 59 
      (56.2%) tumors, respectively, while gain and loss at cCI5-215 occurred in 55 
      (52.4%) and 45 (42.9%) cases, respectively. The frequency of gain at cCI5-215 was 
      significantly correlated with a smaller tumor diameter (7 cm or less, P<0.05), 
      while loss with a larger one (>7 cm, P<0.05). Both loss at cCI5-215 and aneusomy 
      of chromosome 5 were significantly related to poor disease-specific survival 
      (P<0.05). In conclusion, alterations of chromosome 5 (including allelic loss of 
      5q22.3 approximately q23.2) could be a useful genetic marker for predicting the 
      patient prognosis of RCC.
FAU - Nagao, Kazuhiro
AU  - Nagao K
AD  - Department of Urology, Yamaguchi University School of Medicine, 1-1-1, 
      Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan. katsumai@po.cc.yamaguchi-u.ac.jp
FAU - Yoshihiro, Satoru
AU  - Yoshihiro S
FAU - Matsuyama, Hideyasu
AU  - Matsuyama H
FAU - Yamaguchi, Shiro
AU  - Yamaguchi S
FAU - Oba, Kazuo
AU  - Oba K
FAU - Naito, Katsusuke
AU  - Naito K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Renal Cell/*genetics/mortality
MH  - Chromosome Aberrations
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 5
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Kidney Neoplasms/*genetics/mortality
MH  - *Loss of Heterozygosity
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
EDAT- 2002/08/08 10:00
MHDA- 2002/08/21 10:01
CRDT- 2002/08/08 10:00
PHST- 2002/08/08 10:00 [pubmed]
PHST- 2002/08/21 10:01 [medline]
PHST- 2002/08/08 10:00 [entrez]
AID - S0165460802005113 [pii]
AID - 10.1016/s0165-4608(02)00511-3 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2002 Jul 1;136(1):23-30. doi: 
      10.1016/s0165-4608(02)00511-3.