PMID- 12165657
OWN - NLM
STAT- MEDLINE
DCOM- 20030207
LR  - 20191106
IS  - 1046-3976 (Print)
IS  - 1046-3976 (Linking)
VI  - 13
IP  - 2
DP  - 2002 Summer
TI  - N-cadherin expression in adrenal tumors: upregulation in malignant 
      pheochromocytoma and downregulation in adrenocortical carcinoma.
PG  - 99-110
AB  - Cell adhesion molecules (CAMs) are important regulators of tumor growth. The aim 
      of the present study was to evaluate the expression pattern of CAMs in adrenal 
      tumors regarding origin (cortex vs medulla) and biologic behavior (benign vs 
      malignant). Eighty seven adrenal tumors were investigated by immunocytochemistry 
      (ICC) using monoclonal antibodies against N-cadherin (NCAD), E-cadherin (ECAD), 
      neural cell adhesion molecule (NCAM), and CD44. Western blotting was performed on 
      30 tumors using the same antibodies. Markers for proliferation (Ki-67) and 
      catecholamine synthesis (tyrosine hydroxylase) were also analyzed in tumors by 
      ICC. NCAD was expressed in 12/27 benign pheochromocytomas (BPCs) (12 familial 
      cases), 8/8 malignant pheochromocytomas (MPCs), 28/30 adrenocortical adenomas, 
      and 9/22 adrenocortical carcinomas. ECAD was expressed in 0/27 BPCs, 0/8 MPCs, 
      0/30 adrenocortical adenomas, and 2/22 adrenocortical carcinomas. NCAM was 
      expressed in 26/27 BPCs, 7/8 MPCs, 21/30 adrenocortical adenomas, and 17/22 
      adrenocortical carcinomas. CD44 was expressed in 23/27 BPCs, 6/8 MPCs, 7/30 
      adrenocortical adenomas, and 4/22 adrenocortical carcinomas. Both cortical and 
      medullary adrenal tumors expressed NCAD, NCAM, and CD44 but were devoid of ECAD. 
      The expression of CD44 and NCAM did not correlate with the malignant potential of 
      tumors. NCAD was upregulated in MPCs, but downregulated in adrenocortical 
      carcinoma. Thus, NCAD appears to be involved in the development of both cortical 
      and medullary adrenal tumors.
FAU - Khorram-Manesh, Amir
AU  - Khorram-Manesh A
AD  - Lundberg Laboratory for Cancer Research, Department of Surgery, Sahlgrenska 
      University Hospital, Goteborg, Sweden. amir.khorram-manesh@surgery.gu.se
FAU - Ahlman, Hakan
AU  - Ahlman H
FAU - Jansson, Svante
AU  - Jansson S
FAU - Nilsson, Ola
AU  - Nilsson O
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Endocr Pathol
JT  - Endocrine pathology
JID - 9009288
RN  - 0 (Cadherins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Hyaluronan Receptors)
RN  - 0 (Ki-67 Antigen)
RN  - 0 (Neural Cell Adhesion Molecules)
SB  - IM
MH  - Adrenal Gland Neoplasms/*metabolism
MH  - Adrenocortical Adenoma/*metabolism
MH  - Adrenocortical Carcinoma/*metabolism
MH  - Blotting, Western
MH  - Cadherins/biosynthesis
MH  - Cell Adhesion Molecules/*biosynthesis
MH  - Humans
MH  - Hyaluronan Receptors/biosynthesis
MH  - Immunohistochemistry
MH  - Ki-67 Antigen/biosynthesis
MH  - Neural Cell Adhesion Molecules/biosynthesis
MH  - Pheochromocytoma/*metabolism
MH  - Prognosis
MH  - Up-Regulation
EDAT- 2002/08/08 10:00
MHDA- 2003/02/08 04:00
CRDT- 2002/08/08 10:00
PHST- 2002/08/08 10:00 [pubmed]
PHST- 2003/02/08 04:00 [medline]
PHST- 2002/08/08 10:00 [entrez]
AID - EP:13:2:099 [pii]
AID - 10.1385/ep:13:2:099 [doi]
PST - ppublish
SO  - Endocr Pathol. 2002 Summer;13(2):99-110. doi: 10.1385/ep:13:2:099.