PMID- 12165658
OWN - NLM
STAT- MEDLINE
DCOM- 20030207
LR  - 20191106
IS  - 1046-3976 (Print)
IS  - 1046-3976 (Linking)
VI  - 13
IP  - 2
DP  - 2002 Summer
TI  - S-100 protein+ dendritic cells and CD34+ dendritic interstitial cells in thyroid 
      lesions.
PG  - 111-5
AB  - Dendritic cells (DCs) are antigen-presenting cells and mature from precursor 
      CD34+ stromal cells (dendritic interstitial cells [DICs]) or monocytes. The aim 
      of the present study was to gain insight into the local immune response to 
      various thyroid lesions. We investigated, immunohistochemically, the presence of 
      S-100+ DCs and CD34+ DICs in 13 papillary carcinomas, 10 follicular carcinomas, 7 
      follicular adenomas, 1 Hurthle cell carcinoma, 1 Hurthle cell adenoma, 2 
      medullary carcinomas, 6 undifferentiated carcinomas, and 3 nodular goiters. Dense 
      infiltrates of S-100+ DCs were noted in the majority of papillary carcinomas 
      (mean: 66.4), while moderate infiltrates were observed in follicular adenomas 
      (mean: 23.3), follicular carcinomas (mean: 23.5), and undifferentiated carcinomas 
      (mean: 31.6). The remaining lesions showed slight infiltrates of scattered DCs. 
      DICs were noted exclusively in neoplastic lesions, specifically at the periphery 
      and within the tumor capsule. The increased number of DCs in papillary carcinomas 
      is possibly correlated with their good prognosis. The specific distribution of 
      DICs suggests a possible contribution to growth regulation of thyroid neoplasms.
FAU - Batistatou, Anna
AU  - Batistatou A
AD  - Department of Pathology, University of Patras Medical School, Regional University 
      of Patras, Patras, Greece. doulis@pat.forthnet.gr
FAU - Zolota, Vassiliki
AU  - Zolota V
FAU - Scopa, Chrisoula D
AU  - Scopa CD
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Endocr Pathol
JT  - Endocrine pathology
JID - 9009288
RN  - 0 (Antigens, CD34)
RN  - 0 (S100 Proteins)
SB  - IM
MH  - Adenoma/immunology/metabolism
MH  - Adenoma, Oxyphilic/immunology/metabolism
MH  - Antigens, CD34/*biosynthesis/immunology
MH  - Carcinoma, Medullary/immunology/metabolism
MH  - Carcinoma, Papillary/immunology/metabolism
MH  - Dendritic Cells/immunology/*metabolism
MH  - Goiter, Nodular/immunology/*metabolism
MH  - Humans
MH  - S100 Proteins/*biosynthesis/immunology
MH  - Thyroid Neoplasms/immunology/*metabolism
EDAT- 2002/08/08 10:00
MHDA- 2003/02/08 04:00
CRDT- 2002/08/08 10:00
PHST- 2002/08/08 10:00 [pubmed]
PHST- 2003/02/08 04:00 [medline]
PHST- 2002/08/08 10:00 [entrez]
AID - EP:13:2:111 [pii]
AID - 10.1385/ep:13:2:111 [doi]
PST - ppublish
SO  - Endocr Pathol. 2002 Summer;13(2):111-5. doi: 10.1385/ep:13:2:111.