PMID- 12165818
OWN - NLM
STAT- MEDLINE
DCOM- 20020916
LR  - 20151119
IS  - 1432-2218 (Electronic)
IS  - 0930-2794 (Linking)
VI  - 16
IP  - 7
DP  - 2002 Jul
TI  - Preoperative symptom evaluation and esophageal acid infusion predict response to 
      laparoscopic Nissen fundoplication in gastroesophageal reflux patients who 
      present with cough.
PG  - 1037-41
AB  - BACKGROUND: Most patients with cough and gastroesophageal reflux disease (GERD) 
      improve on medical treatment with proton pump inhibitors (PPI). Nonresponders may 
      be considered for antireflux surgery, but the selection of patients is difficult. 
      METHODS: We have performed laparoscopic Nissen fundoplications (LNF) in 677 
      patients. Of these patients, 81% have undergone 6-month follow-up assessment with 
      24-h pH testing, esophageal manometry, symptom scores, and quality-of-life 
      scores. RESULTS: LNF controlled heartburn in 93% and improved cough in 81%. 
      Stepwise multiple regression showed that the preoperative cough score (r = 0.620, 
      p <0.0001) and change in cough on and off PPI (r = 0.296, p = 0.0002) predicted 
      improvement after surgery. A positive result on a randomized acid infusion test 
      was associated with a greater improvement in cough after surgery (p = 0.0243). 
      CONCLUSION: An acid infusion test and assessment of cough on and off PPI may be 
      useful preoperative tools for the selection of patients with cough for LNF.
FAU - Allen, C J
AU  - Allen CJ
AD  - Department of Medicine, St. Joseph's Hospital, McMaster University, 50 Charlton 
      Avenue East, Hamilton, Ontario L8N 4A6, Canada. allencj@mcmaster.ca
FAU - Anvari, M
AU  - Anvari M
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20020326
PL  - Germany
TA  - Surg Endosc
JT  - Surgical endoscopy
JID - 8806653
RN  - QTT17582CB (Hydrochloric Acid)
SB  - IM
MH  - Cough/chemically induced/diagnosis/*etiology/*surgery
MH  - Double-Blind Method
MH  - Esophagus/*drug effects
MH  - Female
MH  - Follow-Up Studies
MH  - Fundoplication/*methods
MH  - Gastroesophageal Reflux/chemically induced/*complications/diagnosis/*surgery
MH  - Heartburn/etiology/surgery
MH  - Humans
MH  - *Hydrochloric Acid/administration & dosage
MH  - Hydrogen-Ion Concentration
MH  - Infusion Pumps
MH  - Laparoscopy/*methods
MH  - Male
MH  - Middle Aged
MH  - Patient Selection
MH  - Predictive Value of Tests
MH  - Preoperative Care/methods
MH  - Quality of Life
MH  - Regression Analysis
EDAT- 2002/08/08 10:00
MHDA- 2002/09/17 10:01
CRDT- 2002/08/08 10:00
PHST- 2001/04/25 00:00 [received]
PHST- 2001/11/28 00:00 [accepted]
PHST- 2002/08/08 10:00 [pubmed]
PHST- 2002/09/17 10:01 [medline]
PHST- 2002/08/08 10:00 [entrez]
AID - 10.1007/s00464-001-8330-4 [doi]
PST - ppublish
SO  - Surg Endosc. 2002 Jul;16(7):1037-41. doi: 10.1007/s00464-001-8330-4. Epub 2002 
      Mar 26.