PMID- 12167170
OWN - NLM
STAT- MEDLINE
DCOM- 20030224
LR  - 20131121
IS  - 0001-6772 (Print)
IS  - 0001-6772 (Linking)
VI  - 175
IP  - 4
DP  - 2002 Aug
TI  - Resistance training increases glucose uptake and transport in rat skeletal 
      muscle.
PG  - 315-23
AB  - The aim of this investigation was to determine if resistance training exercise 
      improved glucose uptake and transport in rodent skeletal muscle. Sprague-Dawley 
      rats were assigned to one of the three groups: control (CON), resistance trained 
      (RT) and aerobic exercise trained (AT). Resistance trained rats were placed in a 
      rodent squat apparatus and performed three sets of 10 repetitions at 75% of their 
      one repetition maximum 3 days week-1 for 12 weeks. Aerobic exercise training 
      consisted of running the rats 3 days week-1 for 45 min over a 12-week period on a 
      motor-driven treadmill (32 m min-1, 15% grade). Following the training period, 
      all animals were subjected to hind limb perfusion in the presence of 500 microU 
      mL-1 insulin. Hind limb glucose uptake was similar in the RT (9.91 +/- 0.7 
      micromol g-1 h-1) and AT (10.23 +/- 1.0 micromol g-1 h-1) animals and 
      significantly greater than control (CON) (6.40 +/- 0.6 micromol g-1 h-1). Rates 
      of 3-O-methyl-d-glucose transport in the RT animals were elevated in the muscles 
      utilized for RT while in the AT animals rates of 3-O-methyl-d-glucose transport 
      were increased in those muscles recruited for running. The increased rates of 
      3-O-methyl-d-glucose transport in the skeletal muscles of the resistance trained 
      and aerobic exercise trained animals appeared to be, in part, because of an 
      increased GLUT4 protein concentration. These findings suggest that both 
      resistance or aerobic training exercise can improve insulin-stimulated skeletal 
      muscle glucose uptake and transport, but the training adaptations are restricted 
      to the muscles recruited for the exercise performance.
FAU - Yaspelkis, B B 3rd
AU  - Yaspelkis BB 3rd
AD  - Exercise Biochemistry Laboratory, Department of Kinesiology, California State 
      University Northridge, Northridge, CA, USA.
FAU - Singh, M K
AU  - Singh MK
FAU - Trevino, B
AU  - Trevino B
FAU - Krisan, A D
AU  - Krisan AD
FAU - Collins, D E
AU  - Collins DE
LA  - eng
GR  - GM-48680/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Acta Physiol Scand
JT  - Acta physiologica Scandinavica
JID - 0370362
RN  - 0 (Glucose Transporter Type 4)
RN  - 0 (Monosaccharide Transport Proteins)
RN  - 0 (Muscle Proteins)
RN  - 0 (Slc2a4 protein, rat)
RN  - 146-72-5 (3-O-Methylglucose)
RN  - 9005-79-2 (Glycogen)
RN  - EC 2.3.3.1 (Citrate (si)-Synthase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - 3-O-Methylglucose/metabolism
MH  - Aerobiosis/physiology
MH  - Animals
MH  - Biological Transport/physiology
MH  - Body Weight
MH  - Citrate (si)-Synthase/metabolism
MH  - Glucose/*metabolism
MH  - Glucose Transporter Type 4
MH  - Glycogen/analysis
MH  - Hexokinase/metabolism
MH  - Male
MH  - Monosaccharide Transport Proteins/analysis
MH  - *Muscle Proteins
MH  - Muscle, Skeletal/anatomy & histology/*metabolism
MH  - Physical Conditioning, Animal/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2002/08/09 10:00
MHDA- 2003/02/25 04:00
CRDT- 2002/08/09 10:00
PHST- 2002/08/09 10:00 [pubmed]
PHST- 2003/02/25 04:00 [medline]
PHST- 2002/08/09 10:00 [entrez]
AID - 998 [pii]
AID - 10.1046/j.1365-201X.2002.00998.x [doi]
PST - ppublish
SO  - Acta Physiol Scand. 2002 Aug;175(4):315-23. doi: 
      10.1046/j.1365-201X.2002.00998.x.