PMID- 12169178
OWN - NLM
STAT- MEDLINE
DCOM- 20021203
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 57
IP  - 9
DP  - 2002 Sep
TI  - Circulating interleukin 16 (IL-16) in children with atopic/eczema dermatitis 
      syndrome (AEDS): a novel serological marker of disease activity.
PG  - 815-20
AB  - BACKGROUND: Chemokines play a central role in atopic eczema/dermatitis syndrome 
      (AEDS). Interleukin 16 (IL-16) has been described as a main cytokine involved in 
      CD4+ cell recruitment during inflammation. Recently the influx of CD4+ 
      lymphocytes has been related to the up-regulation of IL-16 in AEDS skin lesions. 
      Circulating beta-chemokines (Eotaxin and RANTES) and IL-16 were investigated in 
      children with AEDS to correlate their presence with the severity of the disease. 
      We also measured serum levels of soluble CD30 (sCD30), a marker of Th2 immune 
      responses related to AEDS disease activity. METHODS: Serum levels of eotaxin, 
      RANTES, IL-16 and sCD30 were measured by immunoenzymatic assay in paediatric 
      patients with pure AEDS (pAEDS, n = 39); the severity of the disease was graded 
      by SCORAD. Fifteen children with AEDS in presence of respiratory allergy 
      (AEDS+A), 15 with allergic asthma (A) and 20 age-matched healthy donors were 
      investigated as control groups. RESULTS: When compared to normals, high amounts 
      of Eotaxin and IL-16 were detected in sera of pAEDS (P = 0.002; P < 0.0001), 
      AEDS+A (P = 0.02; P = 0.01) and A patients (P = 0.004; P = 0.03) with respect to 
      normals. Serum levels of RANTES were also elevated in pAEDS patients, 
      significantly higher than normals (P = 0.009), whereas no statistically 
      significant differences could be detected between pAEDS and AEDS+A or A groups. 
      IL-16 was progressively increased in the different stages of pAEDS, with a 
      positive correlation between IL-16 and both SCORAD and sCD30 (P < 0.0001). 
      CONCLUSION: We suggest that IL-16 could serve as a useful marker of disease 
      activity in childhood pAEDS.
FAU - Frezzolini, A
AU  - Frezzolini A
AD  - Laboratory of Immunology and Allergology, Department of Immunodermatology, 
      Istituto Demopatico dell'Immacolatea, IDI--IRCCS, Rome, Italy.
FAU - Paradisi, M
AU  - Paradisi M
FAU - Zaffiro, A
AU  - Zaffiro A
FAU - Provini, A
AU  - Provini A
FAU - Cadoni, S
AU  - Cadoni S
FAU - Ruffelli, M
AU  - Ruffelli M
FAU - De Pita, O
AU  - De Pita O
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Biomarkers)
RN  - 0 (CCL11 protein, human)
RN  - 0 (Chemokine CCL11)
RN  - 0 (Chemokine CCL5)
RN  - 0 (Chemokines, CC)
RN  - 0 (Chemotactic Factors, Eosinophil)
RN  - 0 (Interleukin-16)
RN  - 0 (Ki-1 Antigen)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Asthma/blood/complications
MH  - Biomarkers/blood
MH  - Chemokine CCL11
MH  - Chemokine CCL5/blood
MH  - Chemokines, CC/blood
MH  - Chemotactic Factors, Eosinophil/blood
MH  - Child
MH  - Child, Preschool
MH  - Dermatitis, Atopic/blood/complications/*diagnosis
MH  - Humans
MH  - Immunoglobulin E/blood
MH  - Infant
MH  - Interleukin-16/*blood
MH  - Ki-1 Antigen/blood
MH  - Syndrome
EDAT- 2002/08/10 10:00
MHDA- 2002/12/04 04:00
CRDT- 2002/08/10 10:00
PHST- 2002/08/10 10:00 [pubmed]
PHST- 2002/12/04 04:00 [medline]
PHST- 2002/08/10 10:00 [entrez]
AID - 2s3687 [pii]
AID - 10.1034/j.1398-9995.2002.23687.x [doi]
PST - ppublish
SO  - Allergy. 2002 Sep;57(9):815-20. doi: 10.1034/j.1398-9995.2002.23687.x.