PMID- 12169181
OWN - NLM
STAT- MEDLINE
DCOM- 20021203
LR  - 20190822
IS  - 0105-4538 (Print)
IS  - 0105-4538 (Linking)
VI  - 57
IP  - 9
DP  - 2002 Sep
TI  - The association between tumor necrosis factor, HLA-DR alleles, and IgE-mediated 
      asthma in Taiwanese adolescents.
PG  - 831-4
AB  - BACKGROUND: Human leukocyte antigen (HLA) DR genes and the tumor necrosis factor 
      (TNF) gene locus are associated with asthma and IgE production. TNFalpha-308G/A 
      frequencies between Japanese and Caucasians in the UK have been found to be 
      different. The roles of HLA-DRB1 and TNF genotypes are unknown in Taiwanese 
      adolescents with IgE-mediated asthma (I-asthma). METHODS: From the population of 
      a 1996 nation-wide survey, we recruited a random sample for a physical 
      examination, determination of total serum IgE (sIgE), dust-mite-specific IgE, and 
      HLA-DRB1, TNFalpha-308, and LTalphaNcoI polymorphisms by polymerase chain 
      reaction. RESULTS: A total of 80 I-asthmatics and 69 non-asthmatics completed the 
      study. We suggested that I-asthmatics had a higher frequency of the DR13 gene (OR 
      = 8.6, 95% CI = [1.6-161]). The DR13 gene was associated with high sIgE and high 
      dust-mite-specific IgE, especially Dermatophagoides farinae. No TNF haplotype or 
      genotype was associated with I-asthma. The DR13 gene was linked to the 
      LTalphaNcoI*1 allele. When sIgE was adjusted by multiple logistic regression, the 
      risk of I-asthma was much higher for the DR13(+)/LTalphaNcoI*1 haplotype (OR = 
      25.6, 95% CI = [2.2-1378]) than for the others. CONCLUSIONS: In Taiwanese 
      children sensitized to Der f, the DR13(+)/LTalphaNcoI*1 haplotype was associated 
      with a much higher risk of having clinical asthma than any other DR13/LTalphaNcoI 
      haplotype.
FAU - Lin, Ying-Chu
AU  - Lin YC
AD  - Department of Environmental and Occupational Health, National Cheng Kung 
      University, Tainan, Taiwan.
FAU - Lu, Cheng-Chan
AU  - Lu CC
FAU - Su, Huey-Jen
AU  - Su HJ
FAU - Shen, Chen-Yang
AU  - Shen CY
FAU - Lei, Huan-Yao
AU  - Lei HY
FAU - Guo, Yueliang Leon
AU  - Guo YL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 0 (Antigens, Dermatophagoides)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
RN  - 0 (HLA-DR7 Antigen)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Lymphotoxin-alpha)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adolescent
MH  - *Alleles
MH  - Antigens, Dermatophagoides/immunology
MH  - Asthma/*genetics/immunology
MH  - Genotype
MH  - HLA-DR Antigens/*genetics
MH  - HLA-DR Serological Subtypes
MH  - HLA-DR7 Antigen/genetics
MH  - HLA-DRB1 Chains
MH  - Haplotypes
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Linkage Disequilibrium
MH  - Logistic Models
MH  - Lymphotoxin-alpha/genetics
MH  - Polymorphism, Genetic
MH  - Tumor Necrosis Factor-alpha/*genetics
EDAT- 2002/08/10 10:00
MHDA- 2002/12/04 04:00
CRDT- 2002/08/10 10:00
PHST- 2002/08/10 10:00 [pubmed]
PHST- 2002/12/04 04:00 [medline]
PHST- 2002/08/10 10:00 [entrez]
AID - 2s3719 [pii]
AID - 10.1034/j.1398-9995.2002.23719.x [doi]
PST - ppublish
SO  - Allergy. 2002 Sep;57(9):831-4. doi: 10.1034/j.1398-9995.2002.23719.x.