PMID- 12169745
OWN - NLM
STAT- MEDLINE
DCOM- 20021010
LR  - 20171101
IS  - 0025-7931 (Print)
IS  - 0025-7931 (Linking)
VI  - 69
IP  - 4
DP  - 2002
TI  - Elevation of ELISA d-dimer levels in patients with primary pulmonary 
      hypertension.
PG  - 327-9
AB  - BACKGROUND: Vasoconstriction, vascular wall remodeling and thrombosis are 
      considered as possible etiologies of primary pulmonary hypertension (PPH). 
      D-dimer, a degradation product of fibrin, has been increasingly used as a marker 
      and prognostic factor in various diseases. OBJECTIVE: To assess elevated ELISA 
      D-dimer levels as a marker of endogenous fibrinolysis in patients with PPH. 
      PATIENTS AND METHODS: Comparison of ELISA D-dimer levels of 12 PPH patients (11 
      female, 1 male) aged 27-73 years (median 51 years) with those of sex- and 
      age-matched healthy controls. RESULTS: Eleven patients had New York Heart 
      Association (NYHA) class III or IV symptoms, and one patient had NYHA class II 
      symptoms. All patients with PPH were treated with anticoagulants and 
      vasodilators: 5 patients were treated with continuous intravenous prostacyclin, 4 
      patients with continuous UT-15 and 2 patients with intermittent intravenous 
      iloprost. Mean ELISA D-dimer levels +/- SD were significantly higher in the PPH 
      group than in the matched control group (473 +/- 109 vs. 182 +/- 103 ng/ml; mean 
      difference: 291 +/- 79, 95% CI: 240-341, p < 0.0001). CONCLUSION: These results 
      suggest the possible involvement of endogenous fibrinolysis in the 
      pathophysiology of PPH.
CI  - Copyright 2002 S. Karger AG, Basel
FAU - Shitrit, D
AU  - Shitrit D
AD  - Pulmonary Institute, Rabin Medical Center and Sackler School of Medicine/TelAviv, 
      Beilinson Campus, Petach Tikva, Israel.
FAU - Bendayan, D
AU  - Bendayan D
FAU - Rudensky, B
AU  - Rudensky B
FAU - Izbicki, G
AU  - Izbicki G
FAU - Huerta, M
AU  - Huerta M
FAU - Fink, G
AU  - Fink G
FAU - Kramer, M R
AU  - Kramer MR
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Respiration
JT  - Respiration; international review of thoracic diseases
JID - 0137356
RN  - 0 (Biomarkers)
RN  - 0 (Fibrin Fibrinogen Degradation Products)
RN  - 0 (fibrin fragment D)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Fibrin Fibrinogen Degradation Products/*analysis
MH  - Fibrinolysis
MH  - Humans
MH  - Hypertension, Pulmonary/*blood
MH  - Male
MH  - Middle Aged
EDAT- 2002/08/10 10:00
MHDA- 2002/10/11 04:00
CRDT- 2002/08/10 10:00
PHST- 2002/08/10 10:00 [pubmed]
PHST- 2002/10/11 04:00 [medline]
PHST- 2002/08/10 10:00 [entrez]
AID - 63270 [pii]
AID - 10.1159/000063270 [doi]
PST - ppublish
SO  - Respiration. 2002;69(4):327-9. doi: 10.1159/000063270.