PMID- 12170469
OWN - NLM
STAT- MEDLINE
DCOM- 20021001
LR  - 20061115
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 19
IP  - 4
DP  - 2002 Aug
TI  - [Dual-color FISH study on myelodysplastic syndrome with 1;7 translocation].
PG  - 313-6
AB  - OBJECTIVE: To study the myelodysplastic syndrome(MDS) with 1;7 translocation in 
      five cases and to determine further the constitution and origin of centromere of 
      the derivative chromosome resulting from 1;7 translocation. METHODS: Bone marrow 
      chromosome preparation of five cases was made using direct method or short- term 
      culture. Karyotypic analysis was carried out by R-banding technique. Dual-color 
      fluorescence in situ hybridization(FISH) using Spectrum Red and Spectrum Green 
      directly labeled chromosome 1-specific a-satellite DNA probe(red) and chromosome 
      7-specific a-satellite DNA probe(green) was performed in three patients of them. 
      RESULTS: All of the five cases had 1;7 translocation. The centromere of the 
      derivative chromosome 7p/1q was constituted with red and green signals in three 
      of them. CONCLUSION: The result of dual-color FISH confirms that the centromere 
      of the derivative chromosome resulting from 1;7 translocation originated from 
      both centromeres of chromosome 1 and chromosome 7.
FAU - Shen, Yongmei
AU  - Shen Y
AD  - First Affiliated Hospital of Suzhou University, Jiangsu Institute of Hematology, 
      Suzhou, Jiangsu, 215006 P.R.China. uujihsmc@public1.sz.js.cn
FAU - Xue, Yongquan
AU  - Xue Y
FAU - Li, Jianyong
AU  - Li J
FAU - Pan, Jinlan
AU  - Pan J
FAU - Wu, Yafang
AU  - Wu Y
FAU - Guo, Yu
AU  - Guo Y
FAU - Lu, Dingwei
AU  - Lu D
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 1/*genetics
MH  - Chromosomes, Human, Pair 7/*genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*methods
MH  - Karyotyping
MH  - Male
MH  - Myelodysplastic Syndromes/*genetics
MH  - *Translocation, Genetic
EDAT- 2002/08/10 10:00
MHDA- 2002/10/03 04:00
CRDT- 2002/08/10 10:00
PHST- 2002/08/10 10:00 [pubmed]
PHST- 2002/10/03 04:00 [medline]
PHST- 2002/08/10 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2002 Aug;19(4):313-6.