PMID- 12172694
OWN - NLM
STAT- MEDLINE
DCOM- 20030107
LR  - 20131121
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 162
IP  - 4
DP  - 2002 Aug
TI  - Evidence for corticotropin-releasing factor regulation of serotonin in the 
      lateral septum during acute swim stress: adaptation produced by repeated 
      swimming.
PG  - 406-14
AB  - RATIONALE: Swim stress decreases extracellular serotonin (5-HT) levels in the rat 
      lateral septum, and adaptation to this effect occurs with repeated swimming. 
      Corticotropin-releasing factor (CRF) administered into the dorsal raphe nucleus 
      (DRN) also decreases 5-HT release in the lateral septum, suggesting that CRF may 
      mediate the effects of swim stress. OBJECTIVES: The hypothesis that endogenous 
      CRF mediates the reduction of 5-HT levels in the lateral septum evoked by swim 
      stress and is involved in the adaptation that occurs with repeated swim stress 
      was tested. METHODS: Extracellular 5-HT levels in rat lateral septum were 
      quantified by means of in vivo microdialysis. Extracellular single unit activity 
      was recorded from the DRN. RESULTS: Intracerebroventricular (i.c.v.) 
      administration of a CRF receptor antagonist prevented the ability of swim stress 
      to decrease 5-HT release in the lateral septum. Prior exposure to swim stress 
      reduced the ability of both CRF (i.c.v.) and a subsequent swim stress to decrease 
      lateral septum 5-HT release (cross adaptation). Additionally, the effects of CRF, 
      administered into the DRN, on DR neuronal discharge were attenuated in rats with 
      a history of swim stress. Finally, administration of a CRF receptor antagonist 
      (i.c.v.) between two swim stress sessions restored the neurochemical response to 
      swim stress (i.e., 5-HT levels were reduced during the second exposure to swim). 
      CONCLUSIONS: Endogenous CRF modulates 5-HT transmission during acute 
      environmental stress and is also integral to adaptation of the 5-HT response 
      produced by repeated stress. Modulation of the 5-HT system by CRF during acute 
      stress may underlie certain coping behaviors, while stress-induced adaptation of 
      this effect may be involved in psychiatric manifestations of repeated stress.
FAU - Price, Michelle L
AU  - Price ML
AD  - David Mahoney Institute Neurological Sciences, University of Pennsylvania, 
      Philadelphia, PA 19104, USA.
FAU - Kirby, Lynn G
AU  - Kirby LG
FAU - Valentino, Rita J
AU  - Valentino RJ
FAU - Lucki, Irwin
AU  - Lucki I
LA  - eng
GR  - MH 00842/MH/NIMH NIH HHS/United States
GR  - MH 36262/MH/NIMH NIH HHS/United States
GR  - MH 58250/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20020629
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (phenylalanyl corticotropin-releasing factor (12-41))
RN  - 333DO1RDJY (Serotonin)
RN  - 9015-71-8 (Corticotropin-Releasing Hormone)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Corticotropin-Releasing Hormone/*analogs & derivatives/*pharmacology/physiology
MH  - Electrophysiology
MH  - Male
MH  - Microdialysis
MH  - Raphe Nuclei/drug effects/metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Septum of Brain/drug effects/*metabolism
MH  - Serotonin/*metabolism
MH  - Stress, Physiological/physiopathology
MH  - Swimming
MH  - Time Factors
EDAT- 2002/08/13 10:00
MHDA- 2003/01/08 04:00
CRDT- 2002/08/13 10:00
PHST- 2001/12/10 00:00 [received]
PHST- 2002/03/27 00:00 [accepted]
PHST- 2002/08/13 10:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/08/13 10:00 [entrez]
AID - 10.1007/s00213-002-1114-2 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 2002 Aug;162(4):406-14. doi: 
      10.1007/s00213-002-1114-2. Epub 2002 Jun 29.