PMID- 12172917
OWN - NLM
STAT- MEDLINE
DCOM- 20021017
LR  - 20131121
IS  - 0001-6322 (Print)
IS  - 0001-6322 (Linking)
VI  - 104
IP  - 3
DP  - 2002 Sep
TI  - Administration schedule for an ethanol-containing diet in pregnancy affects types 
      of offspring brain malformations.
PG  - 305-12
AB  - In the present study, we administered liquid diets containing ethanol to pregnant 
      rats on different schedules, and examined the cerebral cortex of their pups on 
      gestational day (GD) 21 by immunohistochemistry. The first group of pregnant rats 
      was fed a liquid diet containing 5% (w/v) ethanol during GDs 10-21(5% Et). The 
      second group was fed a liquid diet containing 2.5% (w/v) ethanol on GDs 10-12, a 
      diet containing 4% (w/v) ethanol on GDs 13-15, and a diet containing 5% (w/v) 
      ethanol on GDs 16-21 (2.5-5% Et). Pups of 5% Et dams had leptomeningeal 
      heterotopias mainly in the parietal cortex. In 2.5-5% Et pups, other types of 
      malformations such as grooves, microgyri, stacked-up cortices, and defects of 
      layer I were found. The diet intake and body weight gain of 2.5-5% Et dams were 
      significantly higher than those of 5% Et dams during GDs 11-16. There was no 
      difference in total ethanol consumption during GDs 10-21 between the two groups. 
      However, ethanol consumption on GD 15 in 2.5% Et was higher than in 5% Et. A 
      different schedule for administration of an ethanol-containing diet in pregnancy 
      might induce different types of cerebral malformations in rat fetuses.
FAU - Sakata-Haga, Hiromi
AU  - Sakata-Haga H
AD  - Department of Anatomy and Developmental Neurobiology, University of Tokushima 
      School of Medicine, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan. 
      haga@basic.med.tokushima-u.ac.jp
FAU - Sawada, Kazuhiko
AU  - Sawada K
FAU - Hisano, Setsuji
AU  - Hisano S
FAU - Fukui, Yoshihiro
AU  - Fukui Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020518
PL  - Germany
TA  - Acta Neuropathol
JT  - Acta neuropathologica
JID - 0412041
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Alcohol-Induced Disorders, Nervous System/chemically 
      induced/*embryology/pathology
MH  - Animals
MH  - Cerebral Cortex/*abnormalities/embryology/pathology
MH  - Diet
MH  - Ethanol/administration & dosage/*toxicity
MH  - Female
MH  - Fetal Alcohol Spectrum Disorders/embryology/pathology
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
EDAT- 2002/08/13 10:00
MHDA- 2002/10/18 04:00
CRDT- 2002/08/13 10:00
PHST- 2001/11/27 00:00 [received]
PHST- 2002/02/25 00:00 [revised]
PHST- 2002/02/25 00:00 [accepted]
PHST- 2002/08/13 10:00 [pubmed]
PHST- 2002/10/18 04:00 [medline]
PHST- 2002/08/13 10:00 [entrez]
AID - 10.1007/s00401-002-0560-6 [doi]
PST - ppublish
SO  - Acta Neuropathol. 2002 Sep;104(3):305-12. doi: 10.1007/s00401-002-0560-6. Epub 
      2002 May 18.