PMID- 12173755
OWN - NLM
STAT- MEDLINE
DCOM- 20030106
LR  - 20181130
IS  - 0748-7711 (Print)
IS  - 0748-7711 (Linking)
VI  - 39
IP  - 3
DP  - 2002 May-Jun
TI  - Preliminary study of a genetically engineered spinal cord implant on urinary 
      bladder after experimental spinal cord injury in rats.
PG  - 347-57
AB  - The objective of this study was to determine the effect of neurotrophin-secreting 
      Schwann cell implants on the urinary bladder after spinal cord contusion. One 
      hour after severe spinal cord contusion at the T8 to T11 level, carbon filaments 
      containing nonsecreting Schwann cells, brain-derived neurotrophic factor 
      (BDNF)-secreting Schwann cells, neurotrophin-3 (NT-3)-secreting Schwann cells, or 
      Schwann cells secreting both BDNF and NT-3 were implanted into the spinal cord. 
      Untreated spinal cord injured (SCI) rats and noncontused rats (C) were also 
      studied. Two months after spinal cord injury, cystometry was performed and the 
      bladders were studied using light microscopy. SCI rats had significantly 
      increased bladder mass, thickness, and smooth muscle mass compared to C rats. 
      Bladder capacity of SCI rats and rats with spinal cord implants were both 
      significantly greater than that of C rats. This preliminary study suggests that 
      neurotrophin-secreting Schwann cell implants may lead to improved bladder 
      structure after spinal cord injury.
FAU - Sakamoto, Kyoko
AU  - Sakamoto K
AD  - Department of Urology, Loyola University of Chicago Medical School, Maywood, IL, 
      USA.
FAU - Uvelius, Bengt
AU  - Uvelius B
FAU - Khan, Talat
AU  - Khan T
FAU - Damaser, Margot S
AU  - Damaser MS
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Rehabil Res Dev
JT  - Journal of rehabilitation research and development
JID - 8410047
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbon Fiber)
RN  - 0 (Neurotrophin 3)
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Carbon
MH  - Carbon Fiber
MH  - Cell Culture Techniques/methods
MH  - *Disease Models, Animal
MH  - Female
MH  - Genetic Engineering/*methods
MH  - Implants, Experimental/*standards
MH  - Materials Testing
MH  - Neurotrophin 3/*metabolism
MH  - Organ Size
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Schwann Cells/*metabolism/*transplantation
MH  - Spinal Cord Injuries/*complications
MH  - Thoracic Vertebrae/injuries
MH  - Urinary Bladder, Neurogenic/*etiology/pathology/*therapy
MH  - Urodynamics
EDAT- 2002/08/14 10:00
MHDA- 2003/01/08 04:00
CRDT- 2002/08/14 10:00
PHST- 2002/08/14 10:00 [pubmed]
PHST- 2003/01/08 04:00 [medline]
PHST- 2002/08/14 10:00 [entrez]
PST - ppublish
SO  - J Rehabil Res Dev. 2002 May-Jun;39(3):347-57.