PMID- 12173776
OWN - NLM
STAT- MEDLINE
DCOM- 20030129
LR  - 20110225
IS  - 1121-7138 (Print)
IS  - 1121-7138 (Linking)
VI  - 25
IP  - 3
DP  - 2002 Jul
TI  - Modulatory effect of HHV-6 on MCP-1 production by human monocytes.
PG  - 335-40
AB  - Chemokines represent a large family of proinflammatory proteins that orchestrate 
      leukocyte trafficking to sites of viral infection. Human Herpes virus type 6 
      (HHV-6) is a typical immunosuppressive agent, as suggested by its tropism. In 
      this study the production of monocyte chemoattractant protein-1 (MCP-1) and 
      interleukin-10 (IL-10) by human peripheral blood monocytes was evaluated during 
      HHV-6 infection. Our results demonstrate that HHV-6 infection triggers monocytes 
      to release MCP-1 and IL-10. The addition of exogenous recombinant MCP-1 
      upregulates the release of extracellular virus, whereas does not influence the 
      percentage of viral-antigen positive cells. Furthermore, the addition of 
      monoclonal antibodies anti-IL-10 down-regulates MCP-1 release induced by HHV-6. 
      These findings indicate that IL-10 and MCP-1 production was closely related and 
      that the marked amounts of MCP-1 were supported not only by virus but also by 
      virus-induced IL-10.
FAU - Arena, A
AU  - Arena A
AD  - Department of Surgical Sciences, Policlinico Universitario, University of 
      Messina, Italy.
FAU - Stassi, G
AU  - Stassi G
FAU - Speranza, A
AU  - Speranza A
FAU - Iannello, D
AU  - Iannello D
FAU - Mastroeni, P
AU  - Mastroeni P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Italy
TA  - New Microbiol
JT  - The new microbiologica
JID - 9516291
RN  - 0 (Antigens, Viral)
RN  - 0 (Chemokine CCL2)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Antigens, Viral/immunology/metabolism
MH  - Chemokine CCL2/biosynthesis/*immunology/pharmacology
MH  - Cytopathogenic Effect, Viral/immunology
MH  - Gene Expression Regulation/*immunology
MH  - Herpesviridae Infections/*immunology/metabolism
MH  - Herpesvirus 6, Human/*immunology/metabolism
MH  - Humans
MH  - Interleukin-10/immunology/pharmacology
MH  - Monocytes/*immunology/metabolism/*virology
EDAT- 2002/08/14 10:00
MHDA- 2003/01/30 04:00
CRDT- 2002/08/14 10:00
PHST- 2002/08/14 10:00 [pubmed]
PHST- 2003/01/30 04:00 [medline]
PHST- 2002/08/14 10:00 [entrez]
PST - ppublish
SO  - New Microbiol. 2002 Jul;25(3):335-40.