PMID- 12174171
OWN - NLM
STAT- MEDLINE
DCOM- 20021009
LR  - 20190814
IS  - 0001-6314 (Print)
IS  - 0001-6314 (Linking)
VI  - 106
IP  - 3
DP  - 2002 Sep
TI  - Lack of association between an estrogen receptor 1 gene polymorphism and 
      Parkinson's disease with dementia.
PG  - 128-30
AB  - OBJECTIVE: To test for an association between an estrogen receptor 1 (ESR1) gene 
      polymorphism and Parkinson's disease with dementia (PDD) in Finnish subjects. 
      SUBJECTS AND METHODS: Forty-one clinically demented and pathologically confirmed 
      PDD patients and 59 cognitively intact aged individuals with normal 
      neuropathology were genotyped for the ESR1 PvuII polymorphism. RESULTS: We found 
      no significant differences in the genotype or allele frequencies when the PDD 
      patients were compared with the controls. Nor were there any significant 
      differences in these frequencies when the PDD patients with coexisting 
      Alzheimer's disease pathology were compared with the control group. CONCLUSION: 
      We failed to demonstrate an association between dementia-associated PD and the 
      ESR1 PvuII polymorphism in Finnish subjects.
FAU - Mattila, K M
AU  - Mattila KM
AD  - Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere 
      University Hospital, Finland. kari.m.mattila@uta.fi
FAU - Rinne, J O
AU  - Rinne JO
FAU - Roytta, M
AU  - Roytta M
FAU - Laippala, P
AU  - Laippala P
FAU - Lehtimaki, T
AU  - Lehtimaki T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Acta Neurol Scand
JT  - Acta neurologica Scandinavica
JID - 0370336
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alleles
MH  - Alzheimer Disease/etiology
MH  - Case-Control Studies
MH  - Dementia/epidemiology/etiology/*metabolism
MH  - Female
MH  - Finland/epidemiology
MH  - Genotype
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Parkinson Disease/complications/epidemiology/*metabolism
MH  - *Polymorphism, Genetic
MH  - Receptors, Estrogen/*genetics
MH  - Risk Factors
EDAT- 2002/08/14 10:00
MHDA- 2002/10/10 04:00
CRDT- 2002/08/14 10:00
PHST- 2002/08/14 10:00 [pubmed]
PHST- 2002/10/10 04:00 [medline]
PHST- 2002/08/14 10:00 [entrez]
AID - 1o331 [pii]
AID - 10.1034/j.1600-0404.2002.01331.x [doi]
PST - ppublish
SO  - Acta Neurol Scand. 2002 Sep;106(3):128-30. doi: 10.1034/j.1600-0404.2002.01331.x.