PMID- 12174198
OWN - NLM
STAT- MEDLINE
DCOM- 20021010
LR  - 20190922
IS  - 0742-2822 (Print)
IS  - 0742-2822 (Linking)
VI  - 19
IP  - 5
DP  - 2002 Jul
TI  - Failure of left ventricular hypertrophy to regress after surgery for aortic valve 
      stenosis.
PG  - 359-66
AB  - BACKGROUND: Regression of left ventricular (LV) hypertrophy usually follows 
      surgery for aortic stenosis (AS); however, a significant number of ventricles 
      remain hypertrophied. The extent of this phenomenon, the reasons for failure to 
      regress, and its significance are unclear. METHODS: We investigated 43 patients 
      before and after aortic valve surgery and divided them into two groups: 30 
      patients with regression of LV hypertrophy (Group A) and 13 patients without 
      regression (Group B). Preoperative echocardiographic measurements, clinical 
      status, and operative factors were compared between the two groups. The patients 
      were followed up for 42 +/- 22 months for the occurrence of hospitalization for 
      congestive heart failure (CHF) or death. RESULTS: Preoperatively, the two groups 
      were similar except for an excess of patients in New York Heart Association 
      (NYHA) functional Class IV and a greater incidence of old myocardial infarcts in 
      Group B. Postoperatively, Group B patients had larger LVs with decreased systolic 
      function. This was associated with a poor prognosis (23% mortality and 38% CHF vs 
      0% and 4% for Group A patients, P = 0.0002). Cox regression analysis showed 
      previous myocardial infarction (P < 0.001) and percent mass reduction (P = 0.019) 
      to be independent predictors of CHF or death. CONCLUSIONS: Successful regression 
      of LV mass is difficult to predict before surgery; however, its absence is 
      related strongly to a poor long-term prognosis.
FAU - Lessick, Jonathan
AU  - Lessick J
AD  - Department of Cardiology, Rambam Medical Center, Haifa, Israel.
FAU - Mutlak, Diab
AU  - Mutlak D
FAU - Markiewicz, Walter
AU  - Markiewicz W
FAU - Reisner, Shimon A
AU  - Reisner SA
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Aortic Valve Stenosis/diagnostic imaging/*surgery
MH  - Echocardiography, Doppler
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Failure/*diagnosis/epidemiology/etiology
MH  - Heart Valve Prosthesis Implantation/*adverse effects/methods
MH  - Humans
MH  - Hypertrophy, Left Ventricular/*diagnosis/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Preoperative Care
MH  - Prevalence
MH  - Probability
MH  - Proportional Hazards Models
MH  - Registries
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Statistics, Nonparametric
MH  - Treatment Outcome
EDAT- 2002/08/14 10:00
MHDA- 2002/10/11 04:00
CRDT- 2002/08/14 10:00
PHST- 2002/08/14 10:00 [pubmed]
PHST- 2002/10/11 04:00 [medline]
PHST- 2002/08/14 10:00 [entrez]
AID - 10.1046/j.1540-8175.2002.00359.x [doi]
PST - ppublish
SO  - Echocardiography. 2002 Jul;19(5):359-66. doi: 10.1046/j.1540-8175.2002.00359.x.