PMID- 12174930
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20181130
IS  - 0250-7005 (Print)
IS  - 0250-7005 (Linking)
VI  - 22
IP  - 4
DP  - 2002 Jul-Aug
TI  - Survivin expression in laryngeal squamous cell carcinomas and its prognostic 
      implications.
PG  - 2377-83
AB  - We examined the expression of survivin using immunohistochemistry in 102 cases of 
      laryngeal squamous cell carcinoma (LSCC). Overall, 65.7% (67 out of 102) of 
      tumors were positive for survivin expression and significantly associated with 
      tumor site, poor differentiation, tumor size, lymph node metastasis and advanced 
      stage. Kaplan-Meier analysis showed that survivin expression was significantly 
      associated with shorter disease-free and overall survival respectively. When 
      survivin expression and clinical stage were combined, patients with both 
      survivin-positive and advanced stage (III, IV) revealed poorer disease-free and 
      overall survival when compared with the other cases (p = 0.0002 and p = 0.0002, 
      respectively). Additionally, in early stage (I, II) cases, survivin expression 
      also showed a significant prognostic trend for disease-free and overall survival 
      (p = 0.0727 and p = 0.0701, respectively). By the multivariate analysis, tumor 
      size, lymph node metastasis and survivin expression were independent prognostic 
      factors both in disease-free and overall survival. These findings indicate that 
      survivin expression is associated with unfavorable clinicopathological parameters 
      and represents an independent marker for prognosis of LSCC.
FAU - Dong, Youyi
AU  - Dong Y
AD  - The Department of Physiology, Kagawa Medical University, Kita-Gun, Japan.
FAU - Sui, Li
AU  - Sui L
FAU - Watanabe, Yasuo
AU  - Watanabe Y
FAU - Sugimoto, Katsuyoshi
AU  - Sugimoto K
FAU - Tokuda, Masaaki
AU  - Tokuda M
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
RN  - 0 (BIRC5 protein, human)
RN  - 0 (Chromosomal Proteins, Non-Histone)
RN  - 0 (Inhibitor of Apoptosis Proteins)
RN  - 0 (Microtubule-Associated Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Survivin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/mortality/*pathology
MH  - Chromosomal Proteins, Non-Histone/*analysis
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Inhibitor of Apoptosis Proteins
MH  - Laryngeal Neoplasms/mortality/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - *Microtubule-Associated Proteins
MH  - Middle Aged
MH  - Neoplasm Proteins
MH  - Neoplasm Staging
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Survivin
MH  - Time Factors
EDAT- 2002/08/15 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/08/15 10:00
PHST- 2002/08/15 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/08/15 10:00 [entrez]
PST - ppublish
SO  - Anticancer Res. 2002 Jul-Aug;22(4):2377-83.