PMID- 12175437
OWN - NLM
STAT- MEDLINE
DCOM- 20020918
LR  - 20191210
IS  - 1064-1955 (Print)
IS  - 1064-1955 (Linking)
VI  - 21
IP  - 2
DP  - 2002
TI  - Preeclampsia and calcium-ATPase activity of red cell ghosts from neonatal and 
      maternal blood.
PG  - 97-107
AB  - OBJECTIVE: Determination of Ca-ATPase activity and thiobarbituric acid-reactive 
      substances (TBARS) of red cell ghosts from neonatal and maternal blood of 
      normotensive and preeclamptic women. METHODS: Venous blood was obtained by 
      venipuncture of six nulliparous normotensive and six preeclamptic pregnant women. 
      After cesarean delivery, blood samples were obtained from the umbilical cord of 
      the same patients. Red blood cell ghosts were prepared and assayed for Ca-ATPase 
      activity and TBARS. MAIN OUTCOME MEASURE(S): We expected to find a higher level 
      of TBARS, and consequently, a lower activity of the Ca-ATPase activity of the 
      neonatal samples from preeclamptic mothers. RESULTS: The preeclamptic condition 
      produces a significant diminution of the Ca-ATPase activity in both maternal and 
      neonatal red blood cell ghosts (p<0.001 in both cases). The TBARS of the red cell 
      ghosts are significantly increased with preeclampsia in mothers and their 
      neonates (p<0.001 and p<0.005, respectively). The Ca-ATPase activity of red cell 
      ghosts from neonatal blood is significantly lower than the corresponding values 
      of red cell ghosts from both normotensive and preeclamptic women (p<0.001 in both 
      cases). CONCLUSIONS: Preeclamptic mothers and their neonates show a diminished 
      Ca-ATPase activity and an increased level of TBARS in their red blood cell 
      ghosts.
FAU - Carreiras, Milagros M
AU  - Carreiras MM
AD  - Centro de Biofisica y Bioquimica, Instituto Venezolano de Investigaciones 
      Cientificas, Caracas, 1020A, Venezuela.
FAU - Proverbio, Teresa
AU  - Proverbio T
FAU - Proverbio, Fulgencio
AU  - Proverbio F
FAU - Marin, Reinaldo
AU  - Marin R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Hypertens Pregnancy
JT  - Hypertension in pregnancy
JID - 9421297
RN  - 0 (Thiobarbituric Acid Reactive Substances)
RN  - EC 7.2.2.10 (Calcium-Transporting ATPases)
SB  - IM
MH  - Adult
MH  - Calcium-Transporting ATPases/*blood
MH  - Erythrocyte Membrane/*metabolism
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Lipid Peroxidation
MH  - Phosphorylation
MH  - Pre-Eclampsia/*blood
MH  - Pregnancy
MH  - Thiobarbituric Acid Reactive Substances
EDAT- 2002/08/15 10:00
MHDA- 2002/09/19 10:01
CRDT- 2002/08/15 10:00
PHST- 2002/08/15 10:00 [pubmed]
PHST- 2002/09/19 10:01 [medline]
PHST- 2002/08/15 10:00 [entrez]
AID - 120004027 [pii]
AID - 10.1081/PRG-120004027 [doi]
PST - ppublish
SO  - Hypertens Pregnancy. 2002;21(2):97-107. doi: 10.1081/PRG-120004027.