PMID- 12175488
OWN - NLM
STAT- MEDLINE
DCOM- 20030212
LR  - 20220722
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 114
IP  - 1-2
DP  - 2002 Jun
TI  - A highly conserved novel family of mammalian developmental transcription factors 
      related to Drosophila grainyhead.
PG  - 37-50
AB  - The Drosophila transcription factor Grainyhead regulates several key 
      developmental processes. Three mammalian genes, CP2, LBP-1a and LBP-9 have been 
      previously identified as homologues of grainyhead. We now report the cloning of 
      two new mammalian genes (Mammalian grainyhead (MGR) and Brother-of-MGR (BOM)) and 
      one new Drosophila gene (dCP2) that rewrite the phylogeny of this family. We 
      demonstrate that MGR and BOM are more closely related to grh, whereas CP2, LBP-1a 
      and LBP-9 are descendants of the dCP2 gene. MGR shares the greatest sequence 
      homology with grh, is expressed in tissue-restricted patterns more comparable to 
      grh and binds to and transactivates the promoter of the human Engrailed-1 gene, 
      the mammalian homologue of the key grainyhead target gene, engrailed. This 
      sequence and functional conservation indicates that the new mammalian members of 
      this family play important developmental roles.
CI  - Copyright 2002 Elsevier Science Ireland Ltd.
FAU - Wilanowski, Tomasz
AU  - Wilanowski T
AD  - Rotary Bone Marrow Research Laboratory, Royal Melbourne Hospital Research 
      Foundation, c/o Royal Melbourne Hospital Post Office, Grattan Street, Parkville, 
      Victoria 3050, Australia.
FAU - Tuckfield, Annabel
AU  - Tuckfield A
FAU - Cerruti, Loretta
AU  - Cerruti L
FAU - O'Connell, Sinead
AU  - O'Connell S
FAU - Saint, Robert
AU  - Saint R
FAU - Parekh, Vishwas
AU  - Parekh V
FAU - Tao, Jianning
AU  - Tao J
FAU - Cunningham, John M
AU  - Cunningham JM
FAU - Jane, Stephen M
AU  - Jane SM
LA  - eng
GR  - P01 HL53749-06/HL/NHLBI NIH HHS/United States
GR  - P30 CA 21765/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (ELF1 protein, human)
RN  - 0 (EN1 protein, human)
RN  - 0 (Elf1 protein, mouse)
RN  - 0 (En1 protein, mouse)
RN  - 0 (GRHL2 protein, human)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Lcp2 protein, Drosophila)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Repressor Proteins)
RN  - 0 (TFCP2L1 protein, human)
RN  - 0 (Tfcp2l1 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (UBP1 protein, human)
RN  - 0 (grh protein, Drosophila)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Binding Sites
MH  - Cloning, Molecular
MH  - DNA/metabolism
MH  - DNA-Binding Proteins/*metabolism
MH  - Dimerization
MH  - Drosophila
MH  - Drosophila Proteins
MH  - Embryo, Mammalian/pathology
MH  - Embryo, Nonmammalian
MH  - Evolution, Molecular
MH  - Exons
MH  - Homeodomain Proteins/metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - Protein Binding
MH  - Protein Isoforms
MH  - Protein Structure, Tertiary
MH  - *Repressor Proteins
MH  - Sequence Homology, Amino Acid
MH  - Tissue Distribution
MH  - Transcription Factors/biosynthesis/*metabolism
MH  - Transcription, Genetic
MH  - Transcriptional Activation
EDAT- 2002/08/15 10:00
MHDA- 2003/02/14 04:00
CRDT- 2002/08/15 10:00
PHST- 2002/08/15 10:00 [pubmed]
PHST- 2003/02/14 04:00 [medline]
PHST- 2002/08/15 10:00 [entrez]
AID - S0925477302000461 [pii]
AID - 10.1016/s0925-4773(02)00046-1 [doi]
PST - ppublish
SO  - Mech Dev. 2002 Jun;114(1-2):37-50. doi: 10.1016/s0925-4773(02)00046-1.