PMID- 12176919
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20210206
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 100
IP  - 5
DP  - 2002 Sep 1
TI  - Rta of the human herpesvirus 8/Kaposi sarcoma-associated herpesvirus up-regulates 
      human interleukin-6 gene expression.
PG  - 1919-21
AB  - Human herpesvirus 8 (HHV-8)/Kaposi sarcoma-associated herpesvirus (KSHV) is 
      linked to a number of malignancies thought to be driven by cytokines, including 
      interleukin-6 (IL-6). Rta, a transcriptional activator encoded by HHV-8/KSHV, 
      activates the viral lytic cycle leading to the expression of several viral genes 
      implicated in viral pathogenesis. However, the effect of HHV-8/KSHV Rta on 
      cellular genes has not been reported. We present evidence that the human IL-6 
      (hIL-6) gene is up-regulated by Rta. Rta potently activated (up to 164-fold) the 
      hIL-6 promoter in a dose-dependent manner in a transient transfection reporter 
      system. Rta also induced expression of the endogenous hIL-6 gene, as shown by 
      enzyme-linked immunosorbent assays. Activation of the hIL-6 gene by HHV-8/KSHV 
      supports the role of hIL-6 in the development of these malignancies.
FAU - Deng, Hongyu
AU  - Deng H
AD  - Department of Molecular and Medical Pharmacology, University of California at Los 
      Angeles, 90095-1735, USA.
FAU - Chu, Julia T
AU  - Chu JT
FAU - Rettig, Matthew B
AU  - Rettig MB
FAU - Martinez-Maza, Otoniel
AU  - Martinez-Maza O
FAU - Sun, Ren
AU  - Sun R
LA  - eng
GR  - CA57152/CA/NCI NIH HHS/United States
GR  - CA83525/CA/NCI NIH HHS/United States
GR  - CA91791/CA/NCI NIH HHS/United States
GR  - DE14153/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (Interleukin-6)
RN  - 0 (Rta protein, Human herpesvirus 8)
RN  - 0 (Trans-Activators)
RN  - 0 (Viral Proteins)
SB  - IM
MH  - Cell Line
MH  - *Gene Expression Regulation, Viral
MH  - Herpesvirus 8, Human/*genetics/physiology
MH  - Humans
MH  - Immediate-Early Proteins/*genetics
MH  - Interleukin-6/*genetics
MH  - Sarcoma, Kaposi/etiology/metabolism/virology
MH  - Trans-Activators/*genetics
MH  - Up-Regulation
MH  - Viral Proteins/*genetics
EDAT- 2002/08/15 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/08/15 10:00
PHST- 2002/08/15 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/08/15 10:00 [entrez]
AID - S0006-4971(20)59283-5 [pii]
AID - 10.1182/blood-2002-01-0015 [doi]
PST - ppublish
SO  - Blood. 2002 Sep 1;100(5):1919-21. doi: 10.1182/blood-2002-01-0015.