PMID- 12180273
OWN - NLM
STAT- MEDLINE
DCOM- 20030117
LR  - 20191106
IS  - 1398-5647 (Print)
IS  - 1398-5647 (Linking)
VI  - 4
IP  - 3
DP  - 2002 Jun
TI  - Antidepressants and neuroplasticity.
PG  - 183-94
AB  - OBJECTIVE: We review the literature on the cellular changes that underlie the 
      structural impairments observed in brains of animals exposed to stress and in 
      subjects with depressive disorders. We discuss the molecular, cellular and 
      structural adaptations that underlie the therapeutic responses of different 
      classes of antidepressants and contribute to the adaptive plasticity induced in 
      the brain by these drugs. METHODS: We review results from various clinical and 
      basic research studies. RESULTS: Studies demonstrate that chronic antidepressant 
      treatment increases the rate of neurogenesis in the adult hippocampus. Studies 
      also show that antidepressants up-regulate the cyclic adenosine monophosphate 
      (cAMP) and the neurotrophin signaling pathways involved in plasticity and 
      survival. In vitro and in vivo data provide direct evidence that the 
      transcription factor, cAMP response element-binding protein (CREB) and the 
      neurotrophin, brain derived-neurotrophic factor (BDNF) are key mediators of the 
      therapeutic response to antidepressants. CONCLUSIONS: These results suggest that 
      depression maybe associated with a disruption of mechanisms that govern cell 
      survival and neural plasticity in the brain. Antidepressants could mediate their 
      effects by increasing neurogenesis and modulating the signaling pathways involved 
      in plasticity and survival.
FAU - D'Sa, Carrol
AU  - D'Sa C
AD  - Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, 
      Department of Psychiatry, Yale University School of Medicine, Connecticut Mental 
      Health Center, New Haven, CT, USA.
FAU - Duman, Ronald S
AU  - Duman RS
LA  - eng
GR  - 2 POI MH25642/MH/NIMH NIH HHS/United States
GR  - MH45481/MH/NIMH NIH HHS/United States
GR  - MH53199/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - Denmark
TA  - Bipolar Disord
JT  - Bipolar disorders
JID - 100883596
RN  - 0 (Antidepressive Agents)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/*pharmacology
MH  - Arousal/drug effects/physiology
MH  - Cell Survival/drug effects/physiology
MH  - Depressive Disorder/*physiopathology
MH  - Humans
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Neurons/drug effects/physiology
MH  - Stress, Psychological/*physiopathology
RF  - 92
EDAT- 2002/08/16 10:00
MHDA- 2003/01/18 04:00
CRDT- 2002/08/16 10:00
PHST- 2002/08/16 10:00 [pubmed]
PHST- 2003/01/18 04:00 [medline]
PHST- 2002/08/16 10:00 [entrez]
AID - 10.1034/j.1399-5618.2002.01203.x [doi]
PST - ppublish
SO  - Bipolar Disord. 2002 Jun;4(3):183-94. doi: 10.1034/j.1399-5618.2002.01203.x.