PMID- 12183074
OWN - NLM
STAT- MEDLINE
DCOM- 20021212
LR  - 20231213
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 186
IP  - 1
DP  - 2002 Dec 1
TI  - Dietary soy modulation of biochemical parameters in DMBA-induced mammary tumors.
PG  - 43-8
AB  - The aim of this study was to extend our previous observations on the soy 
      modulation of biochemical parameters in 7,12-dimethylbenz[a]anthracene 
      (DMBA)-induced rat mammary tumors, by simultaneously investigating the expression 
      of estrogen receptor-alpha (ERalpha), estrogen receptor-beta (ERbeta), 
      progesterone receptor (PR), apoptosis, neu, and markers of cell proliferation, 
      such as proliferating cell nuclear antigen (PCNA) by immunohistochemistry. The 
      percentage of ERalpha positive tumors was 65.8% in masses from control animals, 
      and significantly dropped to 36.8% in tumors from soy treated rats (P=0.010). The 
      percentage of ERbeta positive tumors was 70.3% in masses from control animals vs. 
      50.0% in tumors from soy exposed animals (P=0.066). Moreover, the percentage of 
      cases which were both ERalpha and ERbeta positive was significantly lower (17.6%) 
      in soy treated than in control animals (51.3%) (P=0.006). The percentage of PR 
      positive tumors was 34.2% in control animals vs. 2.6% in tumors from soy treated 
      rats (P=0.0006). There were no statistically significant differences in the 
      percentage of tumors positively stained for neu, apoptosis, or PCNA, in control 
      vs. soy treated rats. However, when analyzing the reciprocal correlation among 
      the different biochemical parameters we showed that, in treated animals, the 
      majority of ERalpha positive tumors (91.7%) were also PCNA positive (P=0.036). 
      The median percentage of PCNA positivity was significantly higher in ERalpha 
      positive than in ERalpha negative tumors (25 vs. 5%) (P=0.0031). Moreover, an 
      association was found between PCNA and neu status since all neu positive tumors 
      were also PCNA positive (P=0.011).
FAU - Gallo, Daniela
AU  - Gallo D
AD  - Department of Obstetrics and Gynecology, Catholic University of the Sacred Heart, 
      Lgo A. Gemelli, 8-00168 Rome, Italy.
FAU - Ferrandina, Gabriella
AU  - Ferrandina G
FAU - Giacomelli, Sabrina
AU  - Giacomelli S
FAU - Fruscella, Erika
AU  - Fruscella E
FAU - Zannoni, GianFranco
AU  - Zannoni G
FAU - Morazzoni, Paolo
AU  - Morazzoni P
FAU - Riva, Antonella
AU  - Riva A
FAU - Bombardelli, Ezio
AU  - Bombardelli E
FAU - Mancuso, Salvatore
AU  - Mancuso S
FAU - Scambia, Giovanni
AU  - Scambia G
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 0 (Estrogen Receptor alpha)
RN  - 0 (Estrogen Receptor beta)
RN  - 0 (Proliferating Cell Nuclear Antigen)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
RN  - 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
SB  - IM
MH  - 9,10-Dimethyl-1,2-benzanthracene
MH  - Animals
MH  - Diet
MH  - Estrogen Receptor alpha
MH  - Estrogen Receptor beta
MH  - Female
MH  - Mammary Neoplasms, Experimental/chemically induced/*chemistry/pathology
MH  - Proliferating Cell Nuclear Antigen/analysis
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptors, Estrogen/analysis
MH  - Receptors, Progesterone/analysis
MH  - *Glycine max
EDAT- 2002/08/17 10:00
MHDA- 2002/12/13 04:00
CRDT- 2002/08/17 10:00
PHST- 2002/08/17 10:00 [pubmed]
PHST- 2002/12/13 04:00 [medline]
PHST- 2002/08/17 10:00 [entrez]
AID - S0304383502003269 [pii]
AID - 10.1016/s0304-3835(02)00326-9 [doi]
PST - ppublish
SO  - Cancer Lett. 2002 Dec 1;186(1):43-8. doi: 10.1016/s0304-3835(02)00326-9.