PMID- 12186854
OWN - NLM
STAT- MEDLINE
DCOM- 20021008
LR  - 20220309
IS  - 0021-9525 (Print)
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Linking)
VI  - 158
IP  - 4
DP  - 2002 Aug 19
TI  - Notch1 control of oligodendrocyte differentiation in the spinal cord.
PG  - 709-18
AB  - We have selectively inhibited Notch1 signaling in oligodendrocyte precursors 
      (OPCs) using the Cre/loxP system in transgenic mice to investigate the role of 
      Notch1 in oligodendrocyte (OL) development and differentiation. Early development 
      of OPCs appeared normal in the spinal cord. However, at embryonic day 17.5, 
      premature OL differentiation was observed and ectopic immature OLs were present 
      in the gray matter. At birth, OL apoptosis was strongly increased in Notch1 
      mutant animals. Premature OL differentiation was also observed in the cerebrum, 
      indicating that Notch1 is required for the correct spatial and temporal 
      regulation of OL differentiation in various regions of the central nervous 
      system. These findings establish a widespread function of Notch1 in the late 
      steps of mammalian OPC development in vivo.
FAU - Genoud, Stephane
AU  - Genoud S
AD  - Department of Biology, Institute of Cell Biology, Swiss Federal Institute of 
      Technology, ETH-Honggerberg, CH-8093 Zurich, Switzerland.
FAU - Lappe-Siefke, Corinna
AU  - Lappe-Siefke C
FAU - Goebbels, Sandra
AU  - Goebbels S
FAU - Radtke, Freddy
AU  - Radtke F
FAU - Aguet, Michel
AU  - Aguet M
FAU - Scherer, Steven S
AU  - Scherer SS
FAU - Suter, Ueli
AU  - Suter U
FAU - Nave, Klaus-Armin
AU  - Nave KA
FAU - Mantei, Ned
AU  - Mantei N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20020819
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Membrane Proteins)
RN  - 0 (Notch1 protein, mouse)
RN  - 0 (Receptor, Notch1)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Apoptosis/*physiology
MH  - Cell Differentiation/*physiology
MH  - Membrane Proteins/genetics/*physiology
MH  - Mice
MH  - Mice, Transgenic
MH  - Mutation
MH  - Oligodendroglia/*physiology
MH  - Prosencephalon/physiology
MH  - Receptor, Notch1
MH  - *Receptors, Cell Surface
MH  - Spinal Cord/cytology/*physiology
MH  - *Transcription Factors
PMC - PMC2174019
EDAT- 2002/08/21 10:00
MHDA- 2002/10/09 04:00
PMCR- 2003/02/19
CRDT- 2002/08/21 10:00
PHST- 2002/08/21 10:00 [pubmed]
PHST- 2002/10/09 04:00 [medline]
PHST- 2002/08/21 10:00 [entrez]
PHST- 2003/02/19 00:00 [pmc-release]
AID - 200202002 [pii]
AID - 10.1083/jcb.200202002 [doi]
PST - ppublish
SO  - J Cell Biol. 2002 Aug 19;158(4):709-18. doi: 10.1083/jcb.200202002. Epub 2002 Aug 
      19.