PMID- 12187615
OWN - NLM
STAT- MEDLINE
DCOM- 20030305
LR  - 20191106
IS  - 1526-484X (Print)
IS  - 1526-484X (Linking)
VI  - 12
IP  - 2
DP  - 2002 Jun
TI  - Influence of carbohydrate supplementation on plasma cytokine and neutrophil 
      degranulation responses to high intensity intermittent exercise.
PG  - 145-56
AB  - Ingesting carbohydrate (CHO) beverages during prolonged, continuous heavy 
      exercise results in smaller changes in the plasma concentrations of several 
      cytokines and attenuates a decline in neutrophil function. In contrast, ingesting 
      CHO during prolonged intermittent exercise appears to have negligible influence 
      on these responses, probably due to the overall moderate intensity of these 
      intermittent exercise protocols. Therefore, we examine the effect of CHO 
      ingestion on plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) 
      and lipopolysaccharide (LPS)-stimulated neutrophil degranulation responses to 
      high-intensity intermittent running. Six trained male soccer players performed 2 
      exercise trials, 7 days apart, in a randomized, counterbalanced design. On each 
      occasion, they completed six 15-min periods of intermittent running consisting of 
      maximal sprinting interspersed with less intense periods of running and walking. 
      Subjects consumed either CHO or artificially sweetened placebo (PLA) beverages 
      immediately before and at 15-min intervals during the exercise. At 30 min 
      post-exercise, CHO versus PLA was associated with a higher plasma glucose 
      concentration (p < .01), a lower plasma cortisol and IL-6 concentration (p < 
      .02), and fewer numbers of circulating neutrophils (p < .05). Following the 
      exercise, LPS-stimulated elastase release per neutrophil fell 31% below baseline 
      values on the PLA trial (p = .06) compared with 17% on the CHO trial (p = .30). 
      Plasma TNF-alpha concentration increased following the exercise (main effect of 
      time, p < .001) but was not affected by CHO. These data indicate that CHO 
      ingestion attenuates changes in plasma IL-6 concentration, neutrophil 
      trafficking, and LPS-stimulated neutrophil degranulation in response to 
      intermittent exercise that involves bouts of very high intensity exercise.
FAU - Bishop, Nicolette C
AU  - Bishop NC
AD  - Human Muscle Metabolism Research Group, Department of Physical Education, Sports 
      Science and Recreation Management, Loughborough University, Loughborough, LE11 
      3TU, UK.
FAU - Gleeson, Michael
AU  - Gleeson M
FAU - Nicholas, Ceri W
AU  - Nicholas CW
FAU - Ali, Ajmol
AU  - Ali A
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Interleukins)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - EC 3.4.21.36 (Pancreatic Elastase)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Blood Glucose/analysis/immunology
MH  - Cell Degranulation/*immunology
MH  - Cytokines/*blood/*immunology
MH  - Dietary Carbohydrates/*administration & dosage/*immunology
MH  - *Dietary Supplements
MH  - Exercise/*physiology
MH  - Humans
MH  - Hydrocortisone/blood/immunology
MH  - Interleukins/blood/immunology
MH  - Lipopolysaccharides/blood/immunology
MH  - Male
MH  - Neutrophils/*physiology
MH  - Pancreatic Elastase/blood/immunology
MH  - Reference Values
MH  - Time Factors
MH  - Tumor Necrosis Factor-alpha/immunology
EDAT- 2002/08/22 10:00
MHDA- 2003/03/06 04:00
CRDT- 2002/08/22 10:00
PHST- 2002/08/22 10:00 [pubmed]
PHST- 2003/03/06 04:00 [medline]
PHST- 2002/08/22 10:00 [entrez]
AID - 10.1123/ijsnem.12.2.145 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2002 Jun;12(2):145-56. doi: 
      10.1123/ijsnem.12.2.145.