PMID- 12188032
OWN - NLM
STAT- MEDLINE
DCOM- 20030415
LR  - 20191106
IS  - 1567-5769 (Print)
IS  - 1567-5769 (Linking)
VI  - 2
IP  - 7
DP  - 2002 Jun
TI  - Effect of orally administered Hochu-ekki-to, a Japanese herbal medicine, on 
      contact hypersensitivity caused by repeated application of antigen.
PG  - 901-11
AB  - The effects of oral administration of Hochu-ekki-to (HET; bu-zhong-yi-qi-tang in 
      Chinese), a traditional Japanese and Chinese herbal medicine, on chronic contact 
      hypersensitivity were investigated. HET suppressed ear swelling due to chronic 
      contact hypersensitivity caused by repeated application of 
      2,4,6-trinitro-1-chlorobenzene (TNCB). HET significantly suppressed not only 
      increases in hapten-specific immunoglobulin E (IgE) and IgG1 titer due to 
      repeated application of TNCB, but also total IgE and IgG1 concentration in the 
      serum. Interleukin 4 (IL-4) level in inflamed ear tissue was significantly 
      increased by repeated application of TNCB, and this increase in IL-4 level in the 
      ear was significantly suppressed by oral administration of HET. Interferon gamma 
      (IFN-gamma), IL-2, IL-5, IL-10 and IL-12 levels are not changed as much as IL4 by 
      TNCB and HET did not alter these cytokines as much as IL-4. These results suggest 
      that oral administration of HET suppresses chronic contact hypersensitivity, and 
      it can be assumed that the suppression of serum Ig E and Ig G1 and IL-4 in 
      inflamed ear.
FAU - Nakada, Tsutomu
AU  - Nakada T
AD  - Oriental Medicine Research Center of the Kitasato Institute, Tokyo, Japan.
FAU - Watanabe, Kenji
AU  - Watanabe K
FAU - Matsumoto, Tsukasa
AU  - Matsumoto T
FAU - Santa, Kazuki
AU  - Santa K
FAU - Triizuka, Kazuo
AU  - Triizuka K
FAU - Hanawa, Toshihiko
AU  - Hanawa T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Int Immunopharmacol
JT  - International immunopharmacology
JID - 100965259
RN  - 0 (Antigens)
RN  - 0 (Drugs, Chinese Herbal)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Plant Extracts)
RN  - 0 (bu-zhong-yi-qi-tang)
RN  - Z4ZG7O5SZ9 (Picryl Chloride)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Antigens/toxicity
MH  - Dermatitis, Contact/blood/*drug therapy/immunology
MH  - Drugs, Chinese Herbal/*administration & dosage/isolation & purification
MH  - Ear/physiopathology
MH  - Immunoglobulin G/blood
MH  - Inflammation/blood/drug therapy/physiopathology
MH  - Japan
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phytotherapy/methods
MH  - Picryl Chloride/*toxicity
MH  - Plant Extracts/administration & dosage/isolation & purification
MH  - Plants, Medicinal
EDAT- 2002/08/22 10:00
MHDA- 2003/04/16 05:00
CRDT- 2002/08/22 10:00
PHST- 2002/08/22 10:00 [pubmed]
PHST- 2003/04/16 05:00 [medline]
PHST- 2002/08/22 10:00 [entrez]
AID - S1567-5769(02)00027-9 [pii]
AID - 10.1016/s1567-5769(02)00027-9 [doi]
PST - ppublish
SO  - Int Immunopharmacol. 2002 Jun;2(7):901-11. doi: 10.1016/s1567-5769(02)00027-9.