PMID- 12189113
OWN - NLM
STAT- MEDLINE
DCOM- 20160423
LR  - 20181130
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 41
IP  - 7
DP  - 2002 Jul
TI  - Myocardial matrix metalloproteinase-3 and matrix metalloproteinase inhibitor-1 
      expression in congestive heart failure.
PG  - 453-5
AB  - OBJECTIVE: To study the changes of matrix metalloproteinase-3 (MMP-3) and tissue 
      inhibitor of matrix metalloproteinase-1(TIMP-1) expression during congestive 
      heart failure. METHODS: Using the reverse transcriptase-polymerase chain 
      reaction(RT-PCR) assay, we detected MMP-3 and TIMP-1 expression in 31 patients 
      with rheumatic heart disease (RHD) and 8 health subjects. Cardiac function 
      parameters were measured with echocardiographs. RESULTS: Pathological changes of 
      myocardial tissure in CHF with valvular heart disease showed typical myocardial 
      remodeling. As compared with the control group, the contents of MMP-3 in RHD 
      patients were increased significantly ( P < 0.01). The worse the cardiac 
      function, the higher the contents of MMP-3. TIMP-1 expressions showed a reverse 
      correlation. CONCLUSIONS: It is suggested that the altered expression of MMP-3 
      and TIMP-1 contributes to myocardial remodeling and might lead to the development 
      and progression of congestive heart failure. These changes may induce a direct 
      effect on the progressive deterioration of cardiac function.
FAU - Wang, Xianmei
AU  - Wang X
AD  - Department of Cardiology, Kunming General Hospital, Chengdu Command of PLA, 
      Kunming 650032, China.
FAU - Yang, Lixia
AU  - Yang L
FAU - Qi, Feng
AU  - Qi F
FAU - Et Al
AU  - Et Al
LA  - eng
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
RN  - 0 (Matrix Metalloproteinase Inhibitors)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.35 (Matrix Metalloproteinase 9)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Heart Failure
MH  - Humans
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 2/metabolism
MH  - Matrix Metalloproteinase 9/metabolism
MH  - *Matrix Metalloproteinase Inhibitors
MH  - Myocardium
MH  - *Tissue Inhibitor of Metalloproteinase-1
EDAT- 2002/08/22 10:00
MHDA- 2016/04/24 06:00
CRDT- 2002/08/22 10:00
PHST- 2002/08/22 10:00 [pubmed]
PHST- 2016/04/24 06:00 [medline]
PHST- 2002/08/22 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2002 Jul;41(7):453-5.