PMID- 12189248
OWN - NLM
STAT- MEDLINE
DCOM- 20020906
LR  - 20240509
IS  - 0021-9738 (Print)
IS  - 1558-8238 (Electronic)
IS  - 0021-9738 (Linking)
VI  - 110
IP  - 4
DP  - 2002 Aug
TI  - Expression of cutaneous lymphocyte-associated antigen by CD8(+) T cells specific 
      for a skin-tropic virus.
PG  - 537-48
AB  - Virus-specific CD8(+) T cells traffic to infected tissues to promote clearance of 
      infection. We used herpes simplex virus type 2 (HSV-2) as a model system to 
      investigate CD8(+) T cell trafficking to the skin in humans. Using human 
      leukocyte antigen (HLA) class I tetramers, we observed that HSV-specific CD8(+) T 
      cells in the peripheral blood expressed high levels of cutaneous 
      lymphocyte-associated antigen (CLA). In contrast, CD8(+) T cells specific for 
      non-skin-tropic herpesviruses lacked CLA expression. CLA-positive HSV-2-specific 
      CD8(+) T cells had the characteristics of central memory cells, expressing CCR7, 
      CD62L, and CD28, and they proliferated briskly in response to antigen. CLA is 
      related to a functional E-selectin ligand, and both E-selectin and CLA-positive 
      cells were detected in HSV-2-infected skin. HSV-2-specific T cells adhered to 
      cells transfected with E-selectin. A higher proportion of HSV-specific CD8(+) T 
      cells recovered from herpes lesions express CLA compared with blood, consistent 
      with a role for CLA in skin homing. To our knowledge, this is the first report of 
      expression of tissue-specific adhesion-associated molecules by virus-specific 
      CD8(+) T cells. The evaluation of vaccines for skin and mucosal pathogens should 
      include study of the induction of appropriate tissue-specific homing molecules.
FAU - Koelle, David M
AU  - Koelle DM
AD  - Department of Medicine, Department of Laboratory Medicine, and. Department of 
      Pathobiology, University of Washington, Seattle, Washington 98104, USA.
FAU - Liu, Zhi
AU  - Liu Z
FAU - McClurkan, Christopher M
AU  - McClurkan CM
FAU - Topp, Max S
AU  - Topp MS
FAU - Riddell, Stanley R
AU  - Riddell SR
FAU - Pamer, Eric G
AU  - Pamer EG
FAU - Johnson, Andrew S
AU  - Johnson AS
FAU - Wald, Anna
AU  - Wald A
FAU - Corey, Lawrence
AU  - Corey L
LA  - eng
GR  - R21 AI050132/AI/NIAID NIH HHS/United States
GR  - R01 AI050132/AI/NIAID NIH HHS/United States
GR  - P01 AI030731/AI/NIAID NIH HHS/United States
GR  - AI-30731/AI/NIAID NIH HHS/United States
GR  - AI-50132/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Clin Invest
JT  - The Journal of clinical investigation
JID - 7802877
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (Antigens, Neoplasm)
RN  - 0 (CTAGE1 protein, human)
RN  - 0 (Ligands)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
CIN - J Clin Invest. 2002 Aug;110(4):441-2. PMID: 12189237
MH  - Animals
MH  - Antigens, Differentiation, T-Lymphocyte
MH  - Antigens, Neoplasm
MH  - CD8-Positive T-Lymphocytes/classification/*immunology
MH  - CHO Cells
MH  - Cell Line, Transformed
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Cricetinae
MH  - Herpes Genitalis/diagnosis/*immunology/pathology
MH  - Herpesvirus 2, Human/*immunology
MH  - Humans
MH  - Immunologic Memory
MH  - Immunophenotyping
MH  - Ligands
MH  - Lymphocyte Activation
MH  - Membrane Glycoproteins/*metabolism
MH  - Skin/*immunology/virology
PMC - PMC150419
EDAT- 2002/08/22 10:00
MHDA- 2002/09/07 10:01
PMCR- 2002/08/15
CRDT- 2002/08/22 10:00
PHST- 2002/08/22 10:00 [pubmed]
PHST- 2002/09/07 10:01 [medline]
PHST- 2002/08/22 10:00 [entrez]
PHST- 2002/08/15 00:00 [pmc-release]
AID - 15537 [pii]
AID - 10.1172/JCI15537 [doi]
PST - ppublish
SO  - J Clin Invest. 2002 Aug;110(4):537-48. doi: 10.1172/JCI15537.