PMID- 12191564
OWN - NLM
STAT- MEDLINE
DCOM- 20020913
LR  - 20190826
IS  - 0145-2126 (Print)
IS  - 0145-2126 (Linking)
VI  - 26
IP  - 8
DP  - 2002 Aug
TI  - Relationship between CD4(+)/CD8(+) T cell ratio and T cell activation in multiple 
      myeloma: reference to IL-16.
PG  - 705-11
AB  - We found that the ratio of CD4(+) to CD8(+) T cells (CD4/CD8 ratio) was decreased 
      in patients with multiple myeloma (MM) and that this decrease was significantly 
      related to an increase of human leukocyte antigen (HLA)-DR expression by CD8(+) 
      (but not CD4(+)) T cells (P<0.005). In addition, the serum level of interleukin 
      (IL)-16 was significantly higher in stage III MM patients than in healthy 
      controls (P<0.001). The decrease of CD4(+) T cells in MM may be mediated by 
      activation of CD8(+) T cells derived cytokine IL-16. In addition, these T cell 
      phenotypic changes and the IL-16 level appear to be useful indicators of disease 
      activity.
FAU - Koike, Michiaki
AU  - Koike M
AD  - Department of Internal Medicine, Juntendo University Izu-Nagaoka Hospital, 1129 
      Nagaoka, Izu-Nagaoka, Tagata-gun, Shizuoka, Japan
FAU - Sekigawa, Iwao
AU  - Sekigawa I
FAU - Okada, Makiko
AU  - Okada M
FAU - Matsumoto, Michio
AU  - Matsumoto M
FAU - Iida, Noboru
AU  - Iida N
FAU - Hashimoto, Hiroshi
AU  - Hashimoto H
FAU - Oshimi, Kazuo
AU  - Oshimi K
LA  - eng
PT  - Journal Article
PL  - England
TA  - Leuk Res
JT  - Leukemia research
JID - 7706787
RN  - 0 (Biomarkers)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-16)
SB  - IM
MH  - Biomarkers/blood
MH  - CD4-CD8 Ratio
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Interleukin-16/blood
MH  - Lymphocyte Activation/*immunology
MH  - Male
MH  - Multiple Myeloma/*blood/etiology/immunology
MH  - T-Lymphocytes/immunology/metabolism
EDAT- 2002/08/23 10:00
MHDA- 2002/09/14 10:01
CRDT- 2002/08/23 10:00
PHST- 2002/08/23 10:00 [pubmed]
PHST- 2002/09/14 10:01 [medline]
PHST- 2002/08/23 10:00 [entrez]
AID - S0145212601001928 [pii]
AID - 10.1016/s0145-2126(01)00192-8 [doi]
PST - ppublish
SO  - Leuk Res. 2002 Aug;26(8):705-11. doi: 10.1016/s0145-2126(01)00192-8.