PMID- 12191875
OWN - NLM
STAT- MEDLINE
DCOM- 20021024
LR  - 20190819
IS  - 0378-4274 (Print)
IS  - 0378-4274 (Linking)
VI  - 134
IP  - 1-3
DP  - 2002 Aug 5
TI  - Impact of human variability on the biological monitoring of exposure to toluene, 
      phenol, lead, and mercury: II. Compartmental based toxicokinetic modelling.
PG  - 165-75
AB  - In order to quantify the effect of human variability on a wide range of 
      biological exposure indicators (EIs), a general compartmental model was developed 
      and tested on several chemicals. The model consists of four compartments. In a 
      first step, it was applied to four chemicals: toluene (TOL), phenol (Ph), lead 
      (Pb), and mercury (Hg). Individuals were to be exposed 8 h a day, 5 days a week. 
      Physiological parameter values were set to consider a physical workload of 50 W 
      12 h/day and at rest for the remaining 12 h. Monte Carlo simulations were carried 
      out using realistic distributions of physiological and metabolic parameters. The 
      variability extent index (VEI) and the main parameters of influence were 
      determined for each of the EIs. The results were in agreement with literature 
      data. The present compartmental model provides a fair description of the 
      toxicokinetic (TK) variability of very different chemicals. It will, therefore, 
      further be applied to investigate the variability of a wide range of biological 
      indicators.
FAU - Pierrehumbert, Guillaume
AU  - Pierrehumbert G
AD  - Institute of Occupational Health Sciences, Bugnon 19, 1005 Lausanne, Switzerland. 
      guillaume.pierrehumbert@inst.hospvd.ch
FAU - Droz, Pierre-Olivier
AU  - Droz PO
FAU - Tardif, Robert
AU  - Tardif R
FAU - Charest-Tardif, Ginette
AU  - Charest-Tardif G
FAU - Truchon, Ginette
AU  - Truchon G
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
RN  - 2P299V784P (Lead)
RN  - 339NCG44TV (Phenol)
RN  - 3FPU23BG52 (Toluene)
RN  - FXS1BY2PGL (Mercury)
SB  - IM
MH  - Environmental Monitoring/*methods
MH  - Humans
MH  - Lead/*pharmacokinetics
MH  - Mercury/*pharmacokinetics
MH  - *Models, Biological
MH  - Monte Carlo Method
MH  - Occupational Exposure/*analysis
MH  - Phenol/*pharmacokinetics
MH  - Reproducibility of Results
MH  - Toluene/*adverse effects/*pharmacokinetics
MH  - Workload
EDAT- 2002/08/23 10:00
MHDA- 2002/10/31 04:00
CRDT- 2002/08/23 10:00
PHST- 2002/08/23 10:00 [pubmed]
PHST- 2002/10/31 04:00 [medline]
PHST- 2002/08/23 10:00 [entrez]
AID - S0378427402001868 [pii]
AID - 10.1016/s0378-4274(02)00186-8 [doi]
PST - ppublish
SO  - Toxicol Lett. 2002 Aug 5;134(1-3):165-75. doi: 10.1016/s0378-4274(02)00186-8.