PMID- 12192624
OWN - NLM
STAT- MEDLINE
DCOM- 20030225
LR  - 20221207
IS  - 1359-4184 (Print)
IS  - 1359-4184 (Linking)
VI  - 7
IP  - 7
DP  - 2002
TI  - DRD4 promoter SNPs and gender effects on Extraversion in African Americans.
PG  - 786-9
AB  - There is strong evidence for genetic influences on personality traits. Interest 
      in one such gene, the dopamine D4 receptor (DRD4) grew after an exon III 
      polymorphism was associated with Novelty Seeking and related measures of 
      Extraversion. However, the findings were not confirmed in later studies. 
      Recently, a -521C/T single nucleotide polymorphism (SNP) within the promoter 
      region of the DRD4 gene was found to be related to Novelty Seeking scores in 
      populations from Japan and Hungary. Since little is known about the role DRD4 
      plays in personality in other populations we evaluated if two DRD4 promoter SNPs, 
      -521C/T and -616C/G, were related to personality traits in African Americans. 
      Personality traits were measured by the NEO-FFI in 71 unrelated African 
      Americans. Genotyping was performed using PCR-RFLP. Multivariate analyses of 
      variance (MANOVA) were performed to evaluate the effects of gender and -616 and 
      -521 genotypes on personality traits. A significant three-way interaction effect 
      from gender, -616 genotype, and -521 genotype was observed for Extraversion 
      scores (F(1,54) 5.86, P < 0.02). Subsequent analyses revealed that the 
      association was mainly due to -521C/T genotype among females (P = 0.01). This 
      study provides further evidence that genetic variation within the DRD4 promoter 
      and gender differences contribute to variation in Novelty Seeking behaviors such 
      as Extraversion.
FAU - Bookman, E B
AU  - Bookman EB
AD  - Department of Genetics and Human Genetics, Howard University, Washington, DC 
      20060, USA.
FAU - Taylor, R E
AU  - Taylor RE
FAU - Adams-Campbell, L
AU  - Adams-Campbell L
FAU - Kittles, R A
AU  - Kittles RA
LA  - eng
GR  - 5U24AA11898-03/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Mol Psychiatry
JT  - Molecular psychiatry
JID - 9607835
RN  - 0 (DRD4 protein, human)
RN  - 0 (Receptors, Dopamine D2)
RN  - 137750-34-6 (Receptors, Dopamine D4)
SB  - IM
MH  - Adult
MH  - Black People/genetics
MH  - *Extraversion, Psychological
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Male
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/genetics
MH  - Receptors, Dopamine D2/*genetics
MH  - Receptors, Dopamine D4
MH  - Sex Factors
EDAT- 2002/08/23 10:00
MHDA- 2003/02/26 04:00
CRDT- 2002/08/23 10:00
PHST- 2001/12/02 00:00 [received]
PHST- 2002/01/03 00:00 [revised]
PHST- 2002/01/08 00:00 [accepted]
PHST- 2002/08/23 10:00 [pubmed]
PHST- 2003/02/26 04:00 [medline]
PHST- 2002/08/23 10:00 [entrez]
AID - 10.1038/sj.mp.4001075 [doi]
PST - ppublish
SO  - Mol Psychiatry. 2002;7(7):786-9. doi: 10.1038/sj.mp.4001075.