PMID- 12193222
OWN - NLM
STAT- MEDLINE
DCOM- 20020925
LR  - 20190818
IS  - 0300-9475 (Print)
IS  - 0300-9475 (Linking)
VI  - 56
IP  - 3
DP  - 2002 Sep
TI  - Cross-priming is under control of the relB gene.
PG  - 219-23
AB  - Cross-priming is an important mechanism of intercell transfer of antigenic 
      material leading to the specific activation of cytotoxic T lymphocytes. Dendritic 
      cells (DCs) are considered the central antigen-presenting cell in cross-priming. 
      Here we decided to probe the role of the relB gene, a regulator of DC 
      differentiation, in the in vivo cross-priming of a model tumour antigen, TAP(-/-) 
      murine embryo cells (MEC), expressing human adenovirus type 5 early region 1. To 
      this end, we used relB(-/-) mutant mice to generate bone marrow (BM) chimeras as 
      these possess few residual DC but are capable of initiating CD4+ and CD8+ T-cell 
      responses in vivo. Our results show that relB(-/-) BM chimeras are unable to 
      cross-prime CD8+ T cells, suggesting that the relB gene regulates cross-priming.
FAU - Castiglioni, P
AU  - Castiglioni P
AD  - Department of Medicine and Cancer Center, University of California, San Diego, La 
      Jolla 92093-0837, USA.
FAU - Janssen, E M
AU  - Janssen EM
FAU - Prilliman, K R
AU  - Prilliman KR
FAU - Gerloni, M
AU  - Gerloni M
FAU - Schoenberger, S
AU  - Schoenberger S
FAU - Zanetti, M
AU  - Zanetti M
LA  - eng
GR  - R01 CA77427/CA/NCI NIH HHS/United States
GR  - R21 AI49774/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Scand J Immunol
JT  - Scandinavian journal of immunology
JID - 0323767
RN  - 0 (Antigens)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Relb protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 147337-75-5 (Transcription Factor RelB)
SB  - IM
MH  - Animals
MH  - *Antigen Presentation
MH  - Antigens/immunology/metabolism
MH  - Bone Marrow Transplantation
MH  - Cells, Cultured
MH  - Cytotoxicity Tests, Immunologic
MH  - Langerhans Cells/immunology
MH  - Lymph Nodes/immunology
MH  - Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Protein Transport
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Spleen/cytology/immunology
MH  - T-Lymphocytes, Cytotoxic/*immunology
MH  - Transcription Factor RelB
MH  - Transcription Factors/genetics/*physiology
MH  - Transplantation Chimera
EDAT- 2002/08/24 10:00
MHDA- 2002/09/26 06:00
CRDT- 2002/08/24 10:00
PHST- 2002/08/24 10:00 [pubmed]
PHST- 2002/09/26 06:00 [medline]
PHST- 2002/08/24 10:00 [entrez]
AID - 1144 [pii]
AID - 10.1046/j.1365-3083.2002.01144.x [doi]
PST - ppublish
SO  - Scand J Immunol. 2002 Sep;56(3):219-23. doi: 10.1046/j.1365-3083.2002.01144.x.