PMID- 12194821
OWN - NLM
STAT- MEDLINE
DCOM- 20030311
LR  - 20190728
IS  - 0960-9822 (Print)
IS  - 0960-9822 (Linking)
VI  - 12
IP  - 16
DP  - 2002 Aug 20
TI  - Neurotrophin-4: a survival factor for adult sensory neurons.
PG  - 1401-4
AB  - The nerve growth factor (NGF) family of neurotrophins provides a substantial part 
      of the normal trophic support for sensory neurons during development. Although 
      these neurotrophins, which include Brain-Derived Neurotrophic Factor (BDNF), 
      Neurotrophin-3 (NT-3), and Neurotrophin-4 (NT-4), continue to be expressed into 
      adulthood, there is little evidence that they are survival factors for adult 
      neurons. Here we have examined the age-dependent neurotrophic requirements of a 
      specialized type of mechanoreceptive neuron, called a D-hair receptor, in the 
      dorsal root ganglion (DRG). Studies using knockout mice have demonstrated that 
      the survival of D-hair receptors is dependent upon both NT-3 and NT-4. Here, we 
      show that the time period when D-hair receptors require these two neurotrophins 
      is different. Survival of D-hair receptors depends on NT-3 early in postnatal 
      development and NT-4 later in the mature animal. The age-dependent loss of D-hair 
      neurons in older NT-4 knockout mice was accompanied by a large reduction (78%) in 
      neurons positive for the NT-4 receptor (trkB) together with neuronal apoptosis in 
      the DRG. This is the first evidence that sensory neurons have a physiological 
      requirement for a single neurotrophin for their continued survival in the adult.
FAU - Stucky, Cheryl L
AU  - Stucky CL
AD  - Growth Factor and Regeneration Group, Max Delbruck Institute for Molecular 
      Medicine, D-13122, Berlin-Buch, Germany.
FAU - Shin, Jung-Bum
AU  - Shin JB
FAU - Lewin, Gary R
AU  - Lewin GR
LA  - eng
GR  - NS40538/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Curr Biol
JT  - Current biology : CB
JID - 9107782
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Neurotrophin 3)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - P658DCA9XD (neurotrophin 4)
SB  - IM
MH  - Aging/physiology
MH  - Animals
MH  - Apoptosis/physiology
MH  - Electrophysiology
MH  - In Situ Hybridization
MH  - Mechanoreceptors/cytology/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Nerve Growth Factors/*metabolism
MH  - Neurons, Afferent/cytology/*metabolism
MH  - Neuroprotective Agents/*metabolism
MH  - Neurotrophin 3/genetics/metabolism
MH  - Receptor, trkB/metabolism
EDAT- 2002/08/27 10:00
MHDA- 2003/03/12 04:00
CRDT- 2002/08/27 10:00
PHST- 2002/08/27 10:00 [pubmed]
PHST- 2003/03/12 04:00 [medline]
PHST- 2002/08/27 10:00 [entrez]
AID - S0960-9822(02)01072-2 [pii]
AID - 10.1016/s0960-9822(02)01072-2 [doi]
PST - ppublish
SO  - Curr Biol. 2002 Aug 20;12(16):1401-4. doi: 10.1016/s0960-9822(02)01072-2.