PMID- 12195346
OWN - NLM
STAT- MEDLINE
DCOM- 20020924
LR  - 20071114
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 186
IP  - 5
DP  - 2002 Sep 1
TI  - Comprehensive analysis of human leukocyte antigen class I alleles and cervical 
      neoplasia in 3 epidemiologic studies.
PG  - 598-605
AB  - To comprehensively explore the relationship between human leukocyte antigen (HLA) 
      class I alleles and cervical neoplasia, a subset of participants from 3 large US 
      and Costa Rican cervix studies were typed for HLA class I alleles. Study subjects 
      were women with cervical cancer or high-grade squamous epithelial lesions (HSILs; 
      n=365) or low-grade squamous epithelial lesions (LSILs; n=275) or who were 
      cytologically normal (control subjects; n=681). Allele-disease associations were 
      assessed by logistic regression analysis. Consistent associations across all 
      studies were observed for HLA-CW*0202 with a combined odds ratio of 0.53 (95% 
      confidence interval [CI], 0.29-0.89) for cancer or HSILs and 0.58 (95% CI, 
      0.37-1.04) for LSILs, compared with control subjects and adjusted for study. This 
      finding supports the hypothesis that a single allele may be sufficient to confer 
      protection against cervical neoplasia. Given the relationship between HLA-C and 
      its receptors on natural killer (NK) cells, a role is proposed for NK function in 
      human papillomavirus infection and cervical neoplasia.
FAU - Wang, Sophia S
AU  - Wang SS
AD  - Interdisciplinary Studies Section, Division of Cancer Epidemiology and Genetics, 
      Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD 
      20892-7234, USA. wangso@mail.nih.gov
FAU - Hildesheim, Allan
AU  - Hildesheim A
FAU - Gao, Xiaojiang
AU  - Gao X
FAU - Schiffman, Mark
AU  - Schiffman M
FAU - Herrero, Rolando
AU  - Herrero R
FAU - Bratti, M Concepcion
AU  - Bratti MC
FAU - Sherman, Mark E
AU  - Sherman ME
FAU - Barnes, Willard A
AU  - Barnes WA
FAU - Greenberg, Mitchell D
AU  - Greenberg MD
FAU - McGowan, Larry
AU  - McGowan L
FAU - Mortel, Rodrigue
AU  - Mortel R
FAU - Schwartz, Peter E
AU  - Schwartz PE
FAU - Zaino, Richard J
AU  - Zaino RJ
FAU - Glass, Andrew G
AU  - Glass AG
FAU - Burk, Robert D
AU  - Burk RD
FAU - Karacki, Peter
AU  - Karacki P
FAU - Carrington, Mary
AU  - Carrington M
LA  - eng
GR  - CA-78527/CA/NCI NIH HHS/United States
GR  - CO-12400/CO/NCI NIH HHS/United States
GR  - CP-21081/CP/NCI NIH HHS/United States
GR  - CP-31061/CP/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20020729
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (DNA, Viral)
RN  - 0 (HLA-C Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
CIN - J Infect Dis. 2003 May 15;187(10):1675-6. PMID: 12721951
MH  - *Alleles
MH  - Carcinoma, Squamous Cell/epidemiology/*immunology/virology
MH  - Cohort Studies
MH  - Costa Rica
MH  - DNA, Viral/chemistry/genetics
MH  - Female
MH  - HLA-C Antigens/genetics/immunology
MH  - Histocompatibility Antigens Class I/genetics/*immunology
MH  - Humans
MH  - Logistic Models
MH  - Oregon
MH  - Papillomaviridae/genetics/immunology
MH  - Papillomavirus Infections/genetics/immunology
MH  - Polymerase Chain Reaction
MH  - Tumor Virus Infections/genetics/immunology
MH  - Uterine Cervical Neoplasms/epidemiology/*immunology/virology
EDAT- 2002/08/27 10:00
MHDA- 2002/09/25 06:00
CRDT- 2002/08/27 10:00
PHST- 2002/02/07 00:00 [received]
PHST- 2002/04/04 00:00 [revised]
PHST- 2002/08/27 10:00 [pubmed]
PHST- 2002/09/25 06:00 [medline]
PHST- 2002/08/27 10:00 [entrez]
AID - JID020128 [pii]
AID - 10.1086/342295 [doi]
PST - ppublish
SO  - J Infect Dis. 2002 Sep 1;186(5):598-605. doi: 10.1086/342295. Epub 2002 Jul 29.